Sex and the facilitation of cued fear by prior contextual fear conditioning in rats.

IF 1.8 4区 医学 Q4 NEUROSCIENCES
Learning & memory Pub Date : 2024-09-26 Print Date: 2024-09-01 DOI:10.1101/lm.054010.124
Katherine Vazquez, Kehinde E Cole, Ryan G Parsons
{"title":"Sex and the facilitation of cued fear by prior contextual fear conditioning in rats.","authors":"Katherine Vazquez, Kehinde E Cole, Ryan G Parsons","doi":"10.1101/lm.054010.124","DOIUrl":null,"url":null,"abstract":"<p><p>Previous studies have shown that the formation of new memories can be influenced by prior experience. This includes work using Pavlovian fear conditioning in rodents that has shown that an initial fear conditioning experience can become associated with and facilitate the acquisition of new fear memories, especially when they occur close together in time. However, most of the prior studies used only males as subjects, resulting in questions about the generalizability of the findings from this work. Here we tested whether prior contextual fear conditioning would facilitate later learning of cued fear conditioning in both male and female rats, and if there were differences based on the interval between the two conditioning episodes. Our results showed that levels of cued fear were not influenced by prior contextual fear conditioning or by the interval between training; however, females showed lower levels of cued fear. Freezing behavior in the initial training context differed by sex, with females showing lower levels of contextual fear, and by the type of initial training, with rats given delayed shock showing higher levels of fear than rats given immediate shock during contextual fear conditioning. These results indicate that contextual fear conditioning does not prime subsequent cued fear conditioning and that female rats express lower levels of cued and contextual fear conditioning than males.</p>","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472234/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Learning & memory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/lm.054010.124","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Previous studies have shown that the formation of new memories can be influenced by prior experience. This includes work using Pavlovian fear conditioning in rodents that has shown that an initial fear conditioning experience can become associated with and facilitate the acquisition of new fear memories, especially when they occur close together in time. However, most of the prior studies used only males as subjects, resulting in questions about the generalizability of the findings from this work. Here we tested whether prior contextual fear conditioning would facilitate later learning of cued fear conditioning in both male and female rats, and if there were differences based on the interval between the two conditioning episodes. Our results showed that levels of cued fear were not influenced by prior contextual fear conditioning or by the interval between training; however, females showed lower levels of cued fear. Freezing behavior in the initial training context differed by sex, with females showing lower levels of contextual fear, and by the type of initial training, with rats given delayed shock showing higher levels of fear than rats given immediate shock during contextual fear conditioning. These results indicate that contextual fear conditioning does not prime subsequent cued fear conditioning and that female rats express lower levels of cued and contextual fear conditioning than males.

大鼠的性别与先前情境恐惧条件反射对诱发恐惧的促进作用
以往的研究表明,新记忆的形成会受到先前经验的影响。其中包括利用巴甫洛夫恐惧条件反射在啮齿类动物身上进行的研究,该研究表明,最初的恐惧条件反射经历会与新的恐惧记忆联系起来,并促进新恐惧记忆的获得,尤其是当它们发生的时间很接近时。然而,之前的大多数研究都只使用雄性动物作为研究对象,这就导致研究结果的普遍性受到质疑。在这里,我们测试了先前的情境恐惧条件反射是否会促进雄性和雌性大鼠后来对提示恐惧条件反射的学习,以及这两次条件反射之间的间隔是否存在差异。我们的结果表明,提示恐惧的水平不受先前情境恐惧条件反射或训练间隔的影响;但是,雌性大鼠的提示恐惧水平较低。初始训练情境中的冻结行为因性别和初始训练类型而异,雌性大鼠表现出较低的情境恐惧水平,在情境恐惧条件反射中,给予延迟电击的大鼠比给予立即电击的大鼠表现出更高的恐惧水平。这些结果表明,情境恐惧条件反射不会为随后的提示恐惧条件反射提供素材,而且雌性大鼠比雄性大鼠表现出更低的提示和情境恐惧条件反射水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Learning & memory
Learning & memory 医学-神经科学
CiteScore
3.60
自引率
5.00%
发文量
45
审稿时长
6-12 weeks
期刊介绍: The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信