Prospective Comparison of FOCUS MUSE and Single-Shot Echo-Planar Imaging for Diffusion-Weighted Imaging in Evaluating Thyroid-Associated Ophthalmopathy.

IF 4.4 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Korean Journal of Radiology Pub Date : 2024-10-01 DOI:10.3348/kjr.2024.0177

YunMeng Wang, YuanYuan Cui, JianKun Dai, ShuangShuang Ni, TianRan Zhang, Xin Chen, QinLing Jiang, YuXin Cheng, YiChuan Ma, Tuo Li, Yi Xiao

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引用次数: 0

Abstract

Objective: To prospectively compare single-shot (SS) echo-planar imaging (EPI) and field-of-view optimized and constrained undistorted single-shot multiplexed sensitivity-encoding (FOCUS MUSE) for diffusion-weighted imaging (DWI) in evaluating thyroid-associated ophthalmopathy (TAO).

Materials and methods: SS EPI and FOCUS MUSE DWIs were obtained from 39 patients with TAO (18 male; mean ± standard deviation: 48.3 ± 13.3 years) and 26 healthy controls (9 male; mean ± standard deviation: 43.0 ± 18.5 years). Two radiologists scored the visual image quality using a 4-point Likert scale. The image quality score, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and apparent diffusion coefficient (ADC) of extraocular muscles (EOMs) were compared between the two DWIs. Differences in the ADC of EOMs were also evaluated. The performance of discriminating active from inactive TAO was assessed using receiver operating characteristic curves. The correlation between ADC and clinical activity score (CAS) was analyzed using Spearman correlation.

Results: Compared with SS EPI DWI, FOCUS MUSE DWI demonstrated significantly higher image quality scores (P < 0.001), a higher SNR and CNR on the lateral rectus muscle (LRM) and medial rectus muscle (MRM) (P < 0.05), and a non-significant difference in the ADC of the LRM and MRM. Active TAO showed higher ADC than inactive TAO and healthy controls with both SS EPI and FOCUS MUSE DWIs (P < 0.001). Inactive TAO and healthy controls did not show a significant ADC difference with both DWIs. Compared with SS EPI DWI, FOCUS MUSE DWI demonstrated better discrimination of active from inactive TAO (AUC: 0.925 vs. 0.779; P = 0.007). The ADC was significantly correlated with CAS in SS EPI DWI (r = 0.391, P < 0.001) and FOCUS MUSE DWI (r = 0.645, P < 0.001).

Conclusion: FOCUS MUSE DWI provides better images for evaluating EOMs and better performance in diagnosing active TAO than SS EPI DWI. The application of FOCUS MUSE will facilitate the DWI evaluation of TAO.

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前瞻性比较 FOCUS MUSE 和单次回声-平面成像在评估甲状腺相关性眼病中的弥散加权成像。

目的前瞻性地比较单次（SS）回声平面成像（EPI）和视场优化与约束不失真单次多路灵敏度编码（FOCUS MUSE）扩散加权成像（DWI）在评估甲状腺相关性眼病（TAO）中的应用：从 39 名 TAO 患者（18 名男性；平均 ± 标准偏差：48.3 ± 13.3 岁）和 26 名健康对照者（9 名男性；平均 ± 标准偏差：43.0 ± 18.5 岁）身上获取 SS EPI 和 FOCUS MUSE DWI。两名放射科医生使用 4 点李克特量表对视觉图像质量进行评分。比较了两种 DWI 的图像质量评分、信噪比（SNR）、对比度与噪声比（CNR）以及眼外肌（EOMs）的表观弥散系数（ADC）。还评估了眼外肌 ADC 的差异。使用接收器操作特征曲线评估了区分活动性和非活动性TAO的性能。利用斯皮尔曼相关性分析了ADC与临床活动评分（CAS）之间的相关性：与 SS EPI DWI 相比，FOCUS MUSE DWI 的图像质量评分明显更高（P < 0.001），外侧直肌（LRM）和内侧直肌（MRM）的 SNR 和 CNR 更高（P < 0.05），而 LRM 和 MRM 的 ADC 差异不大。在 SS EPI 和 FOCUS MUSE DWIs 中，活动性 TAO 的 ADC 均高于非活动性 TAO 和健康对照组（P < 0.001）。非活动性TAO和健康对照组在两种DWI中的ADC差异不明显。与 SS EPI DWI 相比，FOCUS MUSE DWI 能更好地区分活跃与非活跃 TAO（AUC：0.925 对 0.779；P = 0.007）。在SS EPI DWI（r = 0.391，P < 0.001）和FOCUS MUSE DWI（r = 0.645，P < 0.001）中，ADC与CAS明显相关：结论：与SS EPI DWI相比，FOCUS MUSE DWI为评估EOM提供了更好的图像，在诊断活动性TAO方面表现更好。FOCUS MUSE的应用将有助于对TAO进行DWI评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Radiology 医学-核医学

CiteScore

10.60

自引率

12.50%

发文量

141

审稿时长

1.3 months

期刊介绍： The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.