In Silico Evaluation of Nanosecond Laser Treatment of Pigmented Lesions Based on Skin Optical Properties Using a Model of Melanosome Disruption Threshold Fluence.

IF 2.2 3区 医学 Q2 DERMATOLOGY
Yu Shimojo, Takahiro Nishimura, Daisuke Tsuruta, Toshiyuki Ozawa, Taro Kono
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Abstract

Objectives: This study aimed to evaluate the efficacy and safety of nanosecond laser treatment of pigmented lesions in silico using a model of melanosome disruption threshold fluence (MDTF) based on skin optical properties.

Methods: Particle size analysis and scanning electron microscopy were performed to determine the threshold fluence for melanosome disruption using a nanosecond laser. By inputting the obtained threshold fluence into the MDTF model and considering the variability in skin optical properties, irradiation parameters were calculated and compared with the results from clinical studies.

Results: The threshold fluences for 532 and 755 nm nanosecond laser irradiation were determined to be 3.0 and 15.0 J/cm2, respectively. In silico analysis showed that the incident fluence for moderately pigmented skin should be 1.2 times that for lightly pigmented skin, whereas it should be 50% lower than that for lightly pigmented skin to achieve the same level of energy deposition. Clinically applied fluences for moderately pigmented skin are at the low end of the calculated range of values, suggesting that the clinical fluence is chosen to minimize energy deposition in normal tissues.

Conclusions: Our results showed that the MDTF model can be used to evaluate nanosecond laser treatments and provide clinical guidance on fluence settings based on laser-tissue interactions in moderately pigmented skin. The in silico method can, therefore, provide a robust and quantitative retrospective evaluation of the treatment effects that accounts for variation in irradiation parameters among patients by combining the MDTF model with the in vivo optical properties of individual skin types.

基于皮肤光学特性的纳秒激光治疗色素病变的硅学评估(使用黑色素体破坏阈值流度模型)。
研究目的本研究旨在利用基于皮肤光学特性的黑色素体破坏阈值通量(MDTF)模型,评估纳秒激光治疗色素病变的有效性和安全性:方法:通过粒度分析和扫描电子显微镜确定使用纳秒激光破坏黑色素体的阈值通量。通过将获得的阈值能量输入 MDTF 模型并考虑皮肤光学特性的可变性,计算出辐照参数并与临床研究结果进行比较:结果:532 纳米和 755 纳米纳秒激光辐照的阈值能量分别为 3.0 焦耳/平方厘米和 15.0 焦耳/平方厘米。硅学分析表明,中度色素沉着皮肤的入射能量应是轻度色素沉着皮肤的 1.2 倍,而轻度色素沉着皮肤的入射能量应比轻度色素沉着皮肤低 50%,才能达到相同的能量沉积水平。中度色素沉着皮肤的临床应用流度处于计算值范围的低端,这表明临床流度的选择是为了尽量减少正常组织的能量沉积:我们的研究结果表明,MDTF 模型可用于评估纳秒激光治疗,并根据中度色素沉着皮肤中激光与组织之间的相互作用,为临床提供能量设置指导。因此,通过将 MDTF 模型与个体皮肤类型的体内光学特性相结合,该硅学方法可以对治疗效果进行稳健、定量的回顾性评估,并考虑到患者之间辐照参数的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
12.50%
发文量
119
审稿时长
1 months
期刊介绍: Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.
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