Blood volume collected for cultures in infants with suspected neonatal sepsis

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2024-09-28 DOI:10.1038/s41372-024-02120-0

Maria S. Rueda, Lamia Soghier, Joseph Campos, Burak Bahar, James E. Bost, Jiaxiang Gai, Rana F. Hamdy

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Abstract

To evaluate blood culture sample volumes, identify factors linked to insufficient samples, and compare volumes among neonates treated for culture-negative-sepsis, sepsis-rule-outs, and bloodstream infections (BSI). Observational cohort of blood cultures collected during NICU stay. Association of age, weight, gender, source, and collection time with lower-than-recommended volumes was determined by logistic regression. Blood culture inocula of patients with culture-negative-sepsis, sepsis rule-out, and BSI were compared using ANOVA. 742 blood cultures were obtained from 292 neonates. Median inoculum was 1 mL (IQR:0.6–1.4), and 259 bottles (35%) had inocula <0.9 mL. Night shift sample collection was associated with lower-than-recommended volumes (p = 0.006). No difference in sample volumes was observed between culture-negative-sepsis, sepsis-rule-outs, and BSI (p = 0.5). Median NICU blood culture volumes align with recommendations. Night shift collections correlate with lower volumes. Sample volumes don’t differ in patients with culture-negative-sepsis, BSI, and sepsis-rule-out, and should not be a justification for longer duration of antibiotics.

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为怀疑患有新生儿败血症的婴儿采集血液进行培养。

目的评估血培养样本量，确定与样本不足有关的因素，并比较因培养阴性败血症、败血症排除和血流感染（BSI）而接受治疗的新生儿的样本量：方法：对新生儿重症监护室住院期间采集的血培养进行观察性队列研究。通过逻辑回归确定年龄、体重、性别、来源和采集时间与低于推荐量的关系。采用方差分析比较了培养阴性败血症、败血症排除和 BSI 患者的血培养接种：从 292 名新生儿中获得了 742 份血液培养物。中位接种量为 1 毫升（IQR:0.6-1.4），259 瓶（35%）有接种结论：新生儿重症监护室血培养量中位数符合建议值。夜班采集量较低。培养阴性-败血症、BSI 和败血症-排除患者的样本量没有差异，不应成为延长抗生素使用时间的理由。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.