Research Progress on the Application of Injectable Hydrogel in Oral Tissue Regeneration

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2024-09-26 DOI:10.1111/jop.13581

Hairong Wang, Biyun Gao

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引用次数: 0

Abstract

Background

Oral and maxillofacial tissue defects resulting from factors such as trauma or infection, can significantly impact both facial function and aesthetics. Additionally, the complex anatomical structure of the face often increases the difficulty of treatment. With the advantages of controlled release, targeted delivery, and enhanced mechanical properties, injectable hydrogels have been investigated for the treatment of oral and maxillofacial diseases. In the field of regeneration, injectable hydrogels have a structure similar to the extracellular matrix (ECM) and are biocompatible, which can be used as scaffolds for tissue regeneration.

Objective

This review aims to summarize the literature on the current status and limitations of injectable hydrogels in the field of oral tissue regeneration.

Methods

We searched Pubmed and Web of Science databases to find and summarize the articles on the application of injectable hydrogels in tissue regeneration.

Conclusions

This review focuses on the current status and limitations of injectable hydrogels in the field of tissue regeneration (periodontal tissue, dentin-pulp complex, bone and cartilage, salivary gland regeneration, and mucosal repair). Although fully studied in animal models, there are still challenges in clinical transformation of injectable hydrogels in promoting tissue regeneration.

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注射水凝胶在口腔组织再生中的应用研究进展。

背景：创伤或感染等因素导致的口腔颌面部组织缺损会严重影响面部功能和美观。此外，面部复杂的解剖结构往往会增加治疗的难度。可注射水凝胶具有控释、定向递送和增强机械性能等优点，已被研究用于治疗口腔和颌面部疾病。在再生领域，可注射水凝胶具有与细胞外基质（ECM）相似的结构和生物相容性，可用作组织再生的支架：本综述旨在总结有关可注射水凝胶在口腔组织再生领域的现状和局限性的文献：我们检索了 Pubmed 和 Web of Science 数据库，查找并总结了有关可注射水凝胶在组织再生中应用的文章：本综述主要介绍了可注射水凝胶在组织再生（牙周组织、牙本质-牙髓复合体、骨和软骨、唾液腺再生和粘膜修复）领域的现状和局限性。虽然在动物模型中进行了充分研究，但注射水凝胶在促进组织再生方面的临床转化仍面临挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.