Expression of Programmed Death Ligand 1 and Indoleamine 2,3-Dioxygenase in Oral Lichen Planus and Oral Lichenoid Lesions

IF 2.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Olli Kemppainen, Andreas Mathlin, Sanna Pasonen-Seppänen, Maria Siponen
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引用次数: 0

Abstract

Background

Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are inflammatory T-cell mediated disorders of the oral mucosa (OM). Both are associated with an increased risk of oral squamous cell carcinoma, with OLL possibly having a higher rate of malignant transformation than OLP. Programmed death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase (IDO) are immunosuppressive molecules possessing inhibitory effect on T-cells and have been implicated in carcinogenesis. The aim of this study was to examine the expression of PD-L1 and IDO in OLP and OLL.

Methods

Sixty-eight formalin-fixed, paraffin-embedded tissue samples diagnosed as OLP, compatible with OLP, or OLL were divided into OLP (n = 39) or OLL (n = 29) groups based on both clinical and histopathological diagnostic criteria. Samples of healthy OM (n = 9) served as controls. Samples were immunohistochemically stained for PD-L1 and IDO, and staining distribution and intensity were evaluated.

Results

Immunohistochemical expression of PD-L1 was increased in the basal and intermediate layers of epithelium in OLP and in lamina propria in both OLP and OLL compared to controls. OLP and OLL showed increased expression of IDO in epithelium and lamina propria compared to controls. PD-L1 staining intensity in the basal epithelial layer, and IDO staining intensity in lamina propria were increased in OLP compared to OLL.

Conclusion

The results indicate that the expression of PD-L1 and IDO increases in OLP and OLL, suggesting that these molecules may play a role in the pathogenesis of both disorders.

Abstract Image

程序性死亡配体 1 和吲哚胺 2,3-Dioxygenase 在口腔扁平苔藓和口腔苔癣中的表达。
背景:口腔扁平苔藓(OLP)和口腔苔藓样病变(OLL)是由 T 细胞介导的口腔黏膜(OM)炎症性疾病。这两种疾病都与口腔鳞状细胞癌的风险增加有关,其中口腔扁平苔藓的恶性转化率可能高于口腔扁平苔藓。程序性死亡配体 1(PD-L1)和吲哚胺 2,3-二氧化酶(IDO)是对 T 细胞有抑制作用的免疫抑制分子,与癌变有关。本研究旨在检测 PD-L1 和 IDO 在 OLP 和 OLL 中的表达:根据临床和组织病理学诊断标准,将68份福尔马林固定、石蜡包埋的组织样本分为OLP组(39人)和OLL组(29人)。健康OM样本(9人)作为对照组。对样本进行PD-L1和IDO免疫组化染色,并评估染色分布和强度:与对照组相比,PD-L1在OLP上皮基底层和中间层以及OLP和OLL固有层的免疫组化表达均有所增加。与对照组相比,OLP和OLL的上皮和固有膜中IDO表达增加。与 OLL 相比,OLP 上皮基底层的 PD-L1 染色强度和固有层的 IDO 染色强度均有所增加:结论:研究结果表明,PD-L1 和 IDO 在 OLP 和 OLL 中的表达增加,表明这些分子可能在这两种疾病的发病机制中发挥作用。
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来源期刊
CiteScore
5.90
自引率
6.10%
发文量
121
审稿时长
4-8 weeks
期刊介绍: The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.
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