Epidemiological linkage between migraine and diabetes mellitus: a systematic review and meta-analysis.

IF 7.3 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Headache and Pain Pub Date : 2024-09-27 DOI:10.1186/s10194-024-01868-2

Woo-Seok Ha, Vinh Khang Nguyen, Min Kyung Chu

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引用次数: 0

Abstract

Background: This study aimed to elucidate the nature and extent of the associations between diabetes mellitus (DM) and migraine through a systematic review and meta-analysis.

Methods: We searched the PubMed, Web of Science, and Scopus databases without a specified start date until June 2, 2024. Cross-sectional and cohort studies analyzing the risk of migraine in individuals with DM and vice versa were included. Studies without at least age and sex adjustments were excluded. Data were extracted to calculate odds ratios (ORs) and hazard ratios (HRs). Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale.

Results: Eight cross-sectional studies (131,361 patients with DM and 1,005,604 patients with migraine) and four cohort studies (103,205 patients with DM patients and 32,197 patients with migraine) were included. Meta-analyses of the cross-sectional studies showed no significant overall association between DM and migraine. Subgroup analyses revealed that type 1 diabetes reduced the odds of having migraine (OR 0.48, 95% confidence interval [CI] 0.30-0.77), while migraine without aura (MO) increased the odds of having DM (OR 1.19, 95% CI 1.02-1.39). The cohort studies indicated that DM decreased the risk of developing migraine (HR 0.83, 95% CI 0.76-0.90), and a history of migraine increased the risk of developing DM (HR 1.09, 95% CI 1.01-1.17).

Conclusions: DM, particularly type 1 diabetes, is negatively associated with migraine occurrence, whereas migraine, especially MO, is positively associated with DM occurrence. However, most of the results remained at a low or very low level of evidence, indicating the need for further research.

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偏头痛与糖尿病之间的流行病学联系：系统回顾与荟萃分析。

背景：本研究旨在通过系统回顾和荟萃分析，阐明糖尿病（DM）与偏头痛之间的关系：本研究旨在通过系统综述和荟萃分析阐明糖尿病（DM）与偏头痛之间关联的性质和程度：我们检索了 PubMed、Web of Science 和 Scopus 数据库，但未注明开始日期，直至 2024 年 6 月 2 日。纳入了分析糖尿病患者偏头痛风险的横断面研究和队列研究，反之亦然。未进行至少年龄和性别调整的研究被排除在外。提取数据以计算几率比（OR）和危险比（HR）。采用纽卡斯尔-渥太华质量评估量表评估偏倚风险：纳入了 8 项横断面研究（131361 名糖尿病患者和 1005604 名偏头痛患者）和 4 项队列研究（103205 名糖尿病患者和 32197 名偏头痛患者）。对横断面研究进行的元分析表明，糖尿病与偏头痛之间总体上没有显著关联。亚组分析显示，1型糖尿病降低了偏头痛的患病几率（OR 0.48，95% 置信区间 [CI] 0.30-0.77），而无先兆偏头痛（MO）增加了糖尿病的患病几率（OR 1.19，95% CI 1.02-1.39）。队列研究表明，DM会降低偏头痛的发病风险（HR 0.83，95% CI 0.76-0.90），而偏头痛病史会增加DM的发病风险（HR 1.09，95% CI 1.01-1.17）：结论：糖尿病（尤其是 1 型糖尿病）与偏头痛的发生呈负相关，而偏头痛（尤其是 MO）与糖尿病的发生呈正相关。然而，大多数结果的证据水平仍然较低或很低，这表明还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Headache and Pain 医学-临床神经学

CiteScore

11.80

自引率

13.50%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data. With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.