Exploring the impact and influence of melanin on frequency-domain near-infrared spectroscopy measurements.

IF 3 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Biomedical Optics Pub Date : 2024-06-01 Epub Date: 2024-09-25 DOI:10.1117/1.JBO.29.S3.S33310

Shidhartho Roy, Jingyi Wu, Jiaming Cao, Joel Disu, Sharadhi Bharadwaj, Elizabeth Meinert-Spyker, Pulkit Grover, Jana M Kainerstorfer, Sossena Wood

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引用次数: 0

Abstract

Significance: Near-infrared spectroscopy (NIRS) is a non-invasive optical method that measures changes in hemoglobin concentration and oxygenation. The measured light intensity is susceptible to reduced signal quality due to the presence of melanin.

Aim: We quantify the influence of melanin concentration on NIRS measurements taken with a frequency-domain near-infrared spectroscopy system using 690 and 830 nm.

Approach: Using a forehead NIRS probe, we measured 35 healthy participants and investigated the correlation between melanin concentration indices, which were determined using a colorimeter, and several key metrics from the NIRS signal. These metrics include signal-to-noise ratio (SNR), two measurements of oxygen saturation (arterial oxygen saturation, ${SpO}_{2}$ , and tissue oxygen saturation, ${StO}_{2}$ ), and optical properties represented by the absorption coefficient ( $μ_{a}$ ) and the reduced scattering coefficient ( $μ_{s}^{'}$ ).

Results: We found a significant negative correlation between the melanin index and the SNR estimated in oxy-hemoglobin signals ( $r_{s} = - 0.489$ , $p = 0.006$ ) and ${SpO}_{2}$ levels ( $r_{s} = - 0.413$ , $p = 0.023$ ). However, no significant changes were observed in the optical properties and ${StO}_{2}$ ( $r_{s} = - 0.146$ , $p = 0.44$ ).

Conclusions: We found that estimated SNR and ${SpO}_{2}$ values show a significant decline and dependence on the melanin index, whereas ${StO}_{2}$ and optical properties do not show any correlation with the melanin index.

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探索黑色素对频域近红外光谱测量的影响。

意义重大：近红外光谱（NIRS）是一种无创光学方法，可测量血红蛋白浓度和氧饱和度的变化。目的：我们使用 690 纳米和 830 纳米频域近红外光谱系统量化了黑色素浓度对近红外光谱测量的影响：我们使用前额近红外光谱探头对 35 名健康参与者进行了测量，并研究了使用色度计测定的黑色素浓度指数与近红外光谱信号的几个关键指标之间的相关性。这些指标包括信噪比（SNR）、两种血氧饱和度测量值（动脉血氧饱和度 SpO 2 和组织血氧饱和度 StO 2）以及以吸收系数（μ a）和还原散射系数（μ s ' ）为代表的光学特性：我们发现黑色素指数与氧合血红蛋白信号（r s = - 0.489，p = 0.006）和 SpO 2 水平（r s = - 0.413，p = 0.023）中估计的信噪比之间存在明显的负相关。然而，在光学特性和 StO 2 方面没有观察到明显的变化 ( r s = - 0.146 , p = 0.44 )：我们发现，估计的信噪比和 SpO 2 值显示出明显的下降并依赖于黑色素指数，而 StO 2 和光学特性与黑色素指数没有任何相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Optics 医学-光学

CiteScore

6.40

自引率

5.70%

发文量

263

审稿时长

2 months

期刊介绍： The Journal of Biomedical Optics publishes peer-reviewed papers on the use of modern optical technology for improved health care and biomedical research.