Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-09-24 DOI:10.1080/10286020.2024.2405224

Pan-Pan Wang, Yan-Dan Liu, Lan-Tian Cui, Gao Li, Long-Xuan Zhao, Mei Jin

引用次数: 0

Abstract

As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [1]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated. It is noteworthy that compound UA-2b has the strongest inhibitory effect on the growth of A549, Hela and HepG2 cancer cells (IC₅₀ = 5.37 ± 0.22 µM, 5.82 ± 0.25 µM and 5.47 ± 0.06 µM, respectively). Compounds OA-2b, OA-6a, OA-6b, UA-2b and UA-6a have the best activity against Escherichia coli 1924 (MIC = 16 μg/ml).

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五环三萜苷衍生物的合成、表征和抗癌、抗菌活性。

五环三萜皂苷作为一种苷类化合物，具有良好的生物活性，如抗癌、抗菌、抗病毒、降血糖等作用 [1]。本文设计并合成了二十四种五环三萜类衍生物，其中包括十二种单糖衍生物。对所有化合物的抗癌效果和抗菌活性进行了评估。值得注意的是，化合物 UA-2b 对 A549、Hela 和 HepG2 癌细胞的生长具有最强的抑制作用（IC50 分别为 5.37 ± 0.22 µM、5.82 ± 0.25 µM 和 5.47 ± 0.06 µM）。化合物 OA-2b、OA-6a、OA-6b、UA-2b 和 UA-6a 对大肠杆菌 1924 的活性最好（MIC = 16 μg/ml）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.