Baroreflex Function in Cardiovascular Disease.

IF 6.7 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiac Failure Pub Date : 2024-09-27 DOI:10.1016/j.cardfail.2024.08.062

Husam M Salah, Richa Gupta, Albert J Hicks, Kiran Mahmood, Nicholas A Haglund, Amarinder S Bindra, Steve M Antoine, Rachel Garcia, Amin Yehya, Dmitry M Yaranov, Pujan P Patel, Jason P Feliberti, Allman T Rollins, Vishal N Rao, Laurie Letarte, Vikram Raje, Amit H Alam, Patrick McCANN, Nirav Y Raval, Brian Howard, Marat Fudim

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Abstract

The baroreflex system is involved in modulating several physiological functions of the cardiovascular system and can modulate cardiac output, blood pressure, and cardiac electrophysiology directly and indirectly. In addition, it is involved in regulating neurohormonal pathways involved in the cardiovascular function, such as the renin-angiotensin-aldosterone system and vasopressin release. Baroreflex dysfunction is characterized by sympathetic overactivation and parasympathetic withdrawal and is associated with several cardiovascular diseases, such as hypertension, heart failure, and coronary artery disease. Targeting the baroreflex system via invasive (eg, baroreflex activation therapy and endovascular baroreceptor amplification) and noninvasive approaches (eg, slow breathing exercises and exercise training) has emerged as a novel pathway to manage cardiovascular diseases. Studies examining the long-term safety and efficacy of such interventions in various cardiovascular diseases are needed.

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心血管疾病中的气压反射功能

气压反射系统参与调节心血管系统的多种生理功能，可直接或间接调节心输出量、血压和心脏电生理学。此外，它还参与调节与心血管功能有关的神经激素通路，如肾素-血管紧张素-醛固酮系统（RAAS）和血管加压素释放。气压反射功能障碍的特点是交感神经过度激活和副交感神经抑制，与多种心血管疾病有关，如高血压、心力衰竭（HF）和冠状动脉疾病（CAD）。通过有创疗法（如气压反射激活疗法和血管内气压感受器放大疗法）和无创疗法（如慢呼吸练习和运动训练）靶向调节气压反射系统已成为控制心血管疾病的新途径。需要对此类干预措施在各种心血管疾病中的长期安全性和有效性进行研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiac Failure 医学-心血管系统

CiteScore

7.80

自引率

8.30%

发文量

653

审稿时长

21 days

期刊介绍： Journal of Cardiac Failure publishes original, peer-reviewed communications of scientific excellence and review articles on clinical research, basic human studies, animal studies, and bench research with potential clinical applications to heart failure - pathogenesis, etiology, epidemiology, pathophysiological mechanisms, assessment, prevention, and treatment.