Mohammad Amin Sari, Paridokht Karimian, Eshrat Beigom Kia, Mehdi Mohebali, Amirhossin Aghakhani, Enayat Darabi, Zohre Fakhrieh-Kashan
{"title":"Seroprevalence of <i>Strongyloides stercoralis</i> Infection in Patients with Hyperlipidemia: A Case-Control Study.","authors":"Mohammad Amin Sari, Paridokht Karimian, Eshrat Beigom Kia, Mehdi Mohebali, Amirhossin Aghakhani, Enayat Darabi, Zohre Fakhrieh-Kashan","doi":"10.18502/ijpa.v19i3.16394","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Strongyloides stercoralis</i> is one of the soil-transmitted helminths (STH) in tropical and subtropical regions. The role of lipid profile has been investigated in the survival of larval stages of helminths, but there is limited information about the role of lipid profiles and strongyloidiasis. Hence, we aimed to investigate the seroprevalence of <i>S. stercoralis</i> infection in patients with hyperlipidemia is compared with the nonhyperlipidemia.</p><p><strong>Methods: </strong>In 2023, participants were selected from the laboratory of Porsina Hospital in Guilan Province, northern Iran and their lipid profiles including TG, CHOL, LDL, HDL, and VLDL were measured. They were divided into two groups of case and control and matched based on sex and age. <i>S. stercoralis</i> Ab (IgG) was measured by ELISA methods, using the NovaTec kit. Finally, statistical analysis was performed.</p><p><strong>Results: </strong>Each case and control group consisted of 105 participants, from 13 to 80 years old. 56.66% were female and 43.33% were male. The seroprevalence of <i>S. stercoralis</i> was found 4.76% in the case group compared to 0.95% in the control group. We found an association between TG fall and VLDL with seroprevalence of <i>S. stercoralis</i> in hyperlipidemia group (<i>P</i>= 0.034), but other lipid profiles did not show a significant association. A significant relationship was found between contact with dogs and seroprevalence of <i>S. stercoralis</i> (<i>P</i>=0.001).</p><p><strong>Conclusion: </strong>The seroprevalence of <i>S. stercoralis</i> in the case group was 5 times higher than the control group. A significant association between TG and VLDL fall with <i>S. stercoralis</i> Ab (IgG) was observed, but future studies with more sample sizes are suggested to investigate the anti-atherogenic effect of <i>S. stercoralis</i>. Also, a genetic assessment of <i>S. stercoralis</i> and the host (humane and dogs) is recommended to research zoonotic potential in epidemic areas.</p>","PeriodicalId":14669,"journal":{"name":"Iranian Journal of Parasitology","volume":"19 3","pages":"341-348"},"PeriodicalIF":0.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417978/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijpa.v19i3.16394","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Strongyloides stercoralis is one of the soil-transmitted helminths (STH) in tropical and subtropical regions. The role of lipid profile has been investigated in the survival of larval stages of helminths, but there is limited information about the role of lipid profiles and strongyloidiasis. Hence, we aimed to investigate the seroprevalence of S. stercoralis infection in patients with hyperlipidemia is compared with the nonhyperlipidemia.
Methods: In 2023, participants were selected from the laboratory of Porsina Hospital in Guilan Province, northern Iran and their lipid profiles including TG, CHOL, LDL, HDL, and VLDL were measured. They were divided into two groups of case and control and matched based on sex and age. S. stercoralis Ab (IgG) was measured by ELISA methods, using the NovaTec kit. Finally, statistical analysis was performed.
Results: Each case and control group consisted of 105 participants, from 13 to 80 years old. 56.66% were female and 43.33% were male. The seroprevalence of S. stercoralis was found 4.76% in the case group compared to 0.95% in the control group. We found an association between TG fall and VLDL with seroprevalence of S. stercoralis in hyperlipidemia group (P= 0.034), but other lipid profiles did not show a significant association. A significant relationship was found between contact with dogs and seroprevalence of S. stercoralis (P=0.001).
Conclusion: The seroprevalence of S. stercoralis in the case group was 5 times higher than the control group. A significant association between TG and VLDL fall with S. stercoralis Ab (IgG) was observed, but future studies with more sample sizes are suggested to investigate the anti-atherogenic effect of S. stercoralis. Also, a genetic assessment of S. stercoralis and the host (humane and dogs) is recommended to research zoonotic potential in epidemic areas.
期刊介绍：
Iranian Journal of Parasitology (IJP) is the official publication of Iranian Society of Parasitology (ISP) launched in 2006. The society was inaugurated in 1994 and pursues the improvement of the knowledge on the parasites and parasitic diseases, exchange of scientific knowledge with foreign societies, publicity activities, and consultation on the parasitic diseases, and intimate relationship among society members.
The main aims of the Journal are: contribution to the field of Parasitology, including all aspects of parasites and parasitic diseases (medical and veterinary) and related fields such as Entomology which may be submitted by scientists from Iran and all over the world.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
