Type III Collagen RNA Level Expression in Pelvic Organ Prolapse: A Systematic Review and Meta-Analysis.

IF 1.8 3区医学 Q3 OBSTETRICS & GYNECOLOGY

International Urogynecology Journal Pub Date : 2024-10-01 DOI:10.1007/s00192-024-05953-7

Akbar Novan Dwi Saputra, Dicky Moch Rizal, Nandia Septiyorini, Muhammad Nurhadi Rahman

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Abstract

Introduction and hypothesis: Changes in the expression of type III collagen have been linked to women's predisposition to pelvic organ prolapse (POP); however, the findings of prior studies have been conflicting. This study was aimed at investigating whether changes in the type III collagen gene expression levels occur in POP development.

Methods: A systematic review and meta-analysis were conducted on research articles that evaluated type III collagen gene expression levels in patients with POP compared with those without the condition. The articles, published between January 2000 and February 2024, were obtained from PubMed, ScienceDirect, Semantic Scholar, and EBSCO databases. Data were analyzed using fixed-effect models, and the pooled standardized mean difference (SMD) was calculated. Cochrane's Review Manager 5.4 was used for the analysis. The aggregated SMD with 95% confidence interval (CI) regarding type III collagen gene expression levels relative to POP development was the main outcome measure. Results with p < 0.05 were considered statistically significant.

Results: Six studies were included in our analysis, comprising 229 POP cases and 139 non-POP cases. Our meta-analysis indicated that patients with POP had higher type III collagen gene expression levels than those without POP (SMD = 0.32; 95% CI: 0.07 to 0.56; p = 0.01).

Conclusion: The results of this study provide evidence that a higher type III collagen gene expression levels is significantly associated with POP.

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骨盆器官脱垂的 III 型胶原蛋白 RNA 水平表达：系统回顾与元分析

引言和假设：Ⅲ型胶原蛋白表达的变化与女性易患盆腔器官脱垂（POP）有关，但之前的研究结果却相互矛盾。本研究旨在探讨 III 型胶原蛋白基因表达水平的变化是否发生在 POP 的发展过程中：方法：我们对评估 POP 患者与非 POP 患者 III 型胶原蛋白基因表达水平的研究文章进行了系统回顾和荟萃分析。文章发表于 2000 年 1 月至 2024 年 2 月，来自 PubMed、ScienceDirect、Semantic Scholar 和 EBSCO 数据库。采用固定效应模型对数据进行分析，并计算汇总的标准化平均差（SMD）。分析使用 Cochrane 的 Review Manager 5.4。主要结果测量指标为Ⅲ型胶原蛋白基因表达水平相对于持久性有机污染物发展的合计SMD及95%置信区间（CI）。结果与 p 结果：我们的分析纳入了六项研究，其中包括 229 例 POP 病例和 139 例非 POP 病例。我们的荟萃分析表明，POP 患者的 III 型胶原蛋白基因表达水平高于非 POP 患者（SMD = 0.32；95% CI：0.07 至 0.56；P = 0.01）：本研究结果证明，III型胶原蛋白基因表达水平较高与POP显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urogynecology Journal 医学-妇产科学

CiteScore

3.80

自引率

22.20%

发文量

406

审稿时长

3-6 weeks

期刊介绍： The International Urogynecology Journal is the official journal of the International Urogynecological Association (IUGA).The International Urogynecology Journal has evolved in response to a perceived need amongst the clinicians, scientists, and researchers active in the field of urogynecology and pelvic floor disorders. Gynecologists, urologists, physiotherapists, nurses and basic scientists require regular means of communication within this field of pelvic floor dysfunction to express new ideas and research, and to review clinical practice in the diagnosis and treatment of women with disorders of the pelvic floor. This Journal has adopted the peer review process for all original contributions and will maintain high standards with regard to the research published therein. The clinical approach to urogynecology and pelvic floor disorders will be emphasized with each issue containing clinically relevant material that will be immediately applicable for clinical medicine. This publication covers all aspects of the field in an interdisciplinary fashion