Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study.

IF 4.8 3区医学 Q2 CELL BIOLOGY

Inflammation Research Pub Date : 2024-10-01 DOI:10.1007/s00011-024-01955-9

Hao Pan, Changqing Jing

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引用次数: 0

Abstract

Background: The role of complement in cancer remains controversial. Whether immune cells and inflammatory factors mediate the pathway from complement to cancer has not been fully elucidated.

Methods: We conducted bidirectional Mendelian randomization (MR) analysis to explore the causal association between complement components and cancer. Meta-analysis was conducted to enhance the robustness of the results. We further explored the mediation roles of immune cells and inflammatory factors in these associations.

Results: Our study identified causal associations between 11 complement components and 12 types of cancer. Furthermore, we identified five immune cells as potential mediators: BAFF-R on IgD + CD38- naive B cell mediated 7.434% of the increased risk for liver cancer from C3; CD4 on CD39 + activated CD4 regulatory T cell mediated 12.384% of the increased risk for biliary tract cancer from CD93; CD25 + + CD45RA + CD4 not regulatory T cell and Basophil %CD33dim HLA DR- CD66b- mediated 7.721% and 7.986% of the increased risk of colorectal cancer from MASP1, respectively; CD45RA on resting CD4 regulatory T cell mediated 11.444% of the increased risk of skin cancer from MASP1.

Conclusion: This study revealed the causal relationships between complement components and certain cancers, with five immune cells as potential mediators.

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免疫细胞介导循环补体与癌症之间的因果关系：孟德尔随机化研究

背景：补体在癌症中的作用仍存在争议。免疫细胞和炎症因子是否介导了从补体到癌症的途径尚未完全阐明：我们进行了双向孟德尔随机化（MR）分析，以探讨补体成分与癌症之间的因果关系。为了提高结果的稳健性，我们进行了元分析。我们进一步探讨了免疫细胞和炎症因子在这些关联中的中介作用：我们的研究发现了 11 种补体成分与 12 种癌症之间的因果关系。此外，我们还发现五种免疫细胞是潜在的中介因子：IgD + CD38- 天真 B 细胞上的 BAFF-R 介导了 C3 导致的肝癌风险增加的 7.434%；CD39 + 激活的 CD4 调节性 T 细胞上的 CD4 介导了 CD93 导致的胆道癌风险增加的 12.384%；CD25 + + CD45RA + CD4 非调节性 T 细胞和嗜碱性粒细胞 %CD33dim HLA DR- CD66b 介导了 7.721%和7.986%的结直肠癌风险增加；静息CD4调节性T细胞上的CD45RA介导了11.444%的皮肤癌风险增加：这项研究揭示了补体成分与某些癌症之间的因果关系，其中五种免疫细胞是潜在的介导因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation Research 医学-免疫学

CiteScore

9.90

自引率

1.50%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.