Effect of Low Dose Glucocorticoid Inhalation on Bronchopulmonary Dysplasia in Premature Infants.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormone and Metabolic Research Pub Date : 2024-09-30 DOI:10.1055/a-2414-3061

Xiaohua Li, Heng Liu

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Abstract

The aim of the study was to explore the effect of low dose glucocorticoid on bronchopulmonary dysplasia in premature infants, to provide new ideas for clinical prevention and cure of bronchopulmonary dysplasia in premature infants. The 144 cases of premature infants were divided into 72 each: control group and experimental group. Control group received routine clinical prevention and cure, while experimental group was received low dose glucocorticoid on the basis of control group. The serum interleukin-10 (IL-10) , interleukin-8 (IL-8), and transforming growth factor-1 (TGF-β1) before and after treatment were compared between two groups. The incidence and severity of bronchopulmonary dysplasia was compared between two groups. The mechanical ventilation time, oxygen inhalation time and hospitalization time in two groups were recorded, and the body mass, head circumference and body length at 30 days after birth were assessed in both groups. After treatment, the serum IL-10 level in experimental group was increased and IL-8, TGF-β1 levels were decreased compared with control group (p <0.05). The incidence rate of bronchopulmonary dysplasia in experimental group was 13.89% and the disease severity in experimental group was significantly reduced (p<0.05). Both groups exhibited no notable adverse reactions (p>0.05). Low-dose glucocorticoids have a significant preventive and therapeutic effect on bronchopulmonary dysplasia in preterm infants, and have a high safety, showing high clinical application value for bronchopulmonary dysplasia in preterm infants.

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小剂量糖皮质激素吸入对早产儿支气管肺发育不良的影响

该研究旨在探讨小剂量糖皮质激素对早产儿支气管肺发育不良的影响，为临床防治早产儿支气管肺发育不良提供新思路。将 144 例早产儿分为对照组和实验组各 72 例。对照组接受常规临床防治，实验组在对照组基础上接受小剂量糖皮质激素治疗。比较两组治疗前后的血清白细胞介素-10（IL-10）、白细胞介素-8（IL-8）和转化生长因子-1（TGF-β1）。比较两组支气管肺发育不良的发生率和严重程度。记录两组的机械通气时间、氧气吸入时间和住院时间，评估两组出生后30天的体重、头围和身长。与对照组相比，实验组治疗后血清IL-10水平升高，IL-8、TGF-β1水平降低（P 0.05）。小剂量糖皮质激素对早产儿支气管肺发育不良有明显的预防和治疗作用，安全性高，对早产儿支气管肺发育不良有较高的临床应用价值。

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来源期刊

Hormone and Metabolic Research 医学-内分泌学与代谢

CiteScore

3.80

自引率

0.00%

发文量

125

审稿时长

3-8 weeks

期刊介绍： Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.