Olezarsen and Plozasiran in Dyslipidemia Management: A Narrative Review of Clinical Trials.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
Gbolahan Olatunji, Ikponmwosa Jude Ogieuhi, Emmanuel Kokori, Ajekiigbe Victor Oluwatomiwa, Oluwafemi Isaiah Ajimotokan, God-Dowell O Odukudu, Samuel Owolabi, Sopuruchukwu Anyacho, Chijindu Nnaemeka Nwakama, Adetola Emmanuel Babalola, Franklin Andibanbang, Nicholas Aderinto
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引用次数: 0

Abstract

Cardiovascular diseases are a worldwide known cause of mortality, often due to dyslipidemia and other modifiable and non-modifiable factors. Rare genetic conditions such as familial chylomicronemia are underdiagnosed and mismanaged. Traditional lipid-lowering therapies, such as statins, often have limitations, such as adverse effects and suboptimal lipid control in certain patient populations. Olezarsen and Plozasiran, as emerging therapies, offer potential benefits by targeting specific pathways involved in lipid metabolism. The asymptomatic presentation and high mortality rate warrant novel agents that can manage dyslipidemia. In this article, olezarsen and plozasiran are thoroughly reviewed. From clinical trials, plozasiran significantly improved non-HDL cholesterol levels, highlighting its comprehensive lipid-modifying effects. Olezarsen also demonstrated remarkable efficacy in reducing fasting triglycerides from baseline levels. Utilizing these medications for primary and secondary prevention of atherosclerotic cardiovascular diseases can significantly reduce the global burden of cardiovascular disease and its complications. The review discusses the therapeutic effects of Olezarsen and Plozasiran in managing dyslipidemia, especially familial chylomicronemia syndrome (FCS). While traditional treatments like lifestyle modifications and statins are common, novel antisense oligonucleotides such as Olezarsen and Plozasiran have significant modulatory effects on apolipoproteins, disrupting specific genes involved in lipid metabolism.

血脂异常治疗中的奥利泽生和普乐沙西兰:临床试验综述。
心血管疾病是全世界已知的致死原因,通常是由于血脂异常和其他可改变和不可改变的因素造成的。家族性乳糜微粒血症等罕见的遗传性疾病诊断不足、管理不当。传统的降脂疗法,如他汀类药物,往往有其局限性,如不良反应和某些患者血脂控制不理想。奥利泽生和普乐沙西兰作为新兴疗法,通过靶向参与脂质代谢的特定途径,提供了潜在的益处。由于无症状表现和高死亡率,因此需要能够控制血脂异常的新型药物。本文将对奥利泽生和plozasiran进行详细综述。从临床试验来看,plozasiran 能明显改善非高密度脂蛋白胆固醇水平,突出了其全面的调脂作用。奥利泽生在从基线水平降低空腹甘油三酯方面也显示出显著疗效。将这些药物用于动脉粥样硬化性心血管疾病的一级和二级预防,可大大减轻心血管疾病及其并发症的全球负担。本综述讨论了奥利泽生和普乐沙西兰在控制血脂异常,尤其是家族性乳糜微粒血症综合征(FCS)方面的治疗效果。生活方式调整和他汀类药物等传统治疗方法很常见,而 Olezarsen 和 Plozasiran 等新型反义寡核苷酸对脂蛋白有显著的调节作用,能干扰参与脂质代谢的特定基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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