Influence of vitamin D-calcium on metabolic profile for gestational diabetes: a meta-analysis of randomized controlled trials.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI:10.1080/09513590.2024.2409139

Jin Wang, Qiong Chen, Shaomin Zhang

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引用次数: 0

Abstract

Introduction: The use of vitamin D-calcium supplementation for treating gestational diabetes remains unclear. This meta-analysis aims to evaluate the efficacy of vitamin D-calcium supplementation in the treatment of gestational diabetes.

Methods: Several databases including PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systemically searched from inception to August 2023, and we included the randomized controlled trials (RCTs) assessing the effect of vitamin D-calcium supplementation on the metabolic profile of gestational diabetes.

Results: We included five eligible RCTs and 306 pregnant women in this meta-analysis. Compared with control group in pregnant women with gestational diabetes, vitamin D-calcium supplementation was associated with remarkably decreased fasting plasma glucose (SMD=-0.67; 95% CI=-0.93 to -0.41; p <0.00001), serum insulin (SMD=-1.09; 95% CI=-1.89 to -0.29; p = .007) and LDL (SMD=-0.35; 95% CI=-0.63 to -0.06; p = .02), but demonstrated no impact on total cholesterol (SMD=-0.05; 95% CI=-0.81 to 0.71; p = .90) or triglycerides (SMD=-0.14; 95% CI=-0.86 to 0.58; p = .70).

Conclusions: Vitamin D-calcium supplementation is effective to improve metabolic profile for the treatment of gestational diabetes.

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维生素 D-钙对妊娠糖尿病代谢概况的影响：随机对照试验荟萃分析。

导言：维生素D-钙补充剂用于治疗妊娠糖尿病的效果尚不明确。本荟萃分析旨在评估维生素 D-钙补充剂治疗妊娠糖尿病的疗效：方法：系统检索了从开始到2023年8月的多个数据库，包括PubMed、EMbase、Web of science、EBSCO和Cochrane图书馆数据库，并纳入了评估维生素D-钙补充剂对妊娠糖尿病代谢特征影响的随机对照试验（RCT）：本次荟萃分析共纳入了 5 项符合条件的随机对照试验和 306 名孕妇。与妊娠糖尿病孕妇对照组相比，维生素 D 钙补充剂与空腹血浆葡萄糖（SMD=-0.67；95% CI=-0.93~-0.41；P P = .007）和低密度脂蛋白（SMD=-0.35；95% CI=-0.63至-0.06；P = .02），但对总胆固醇（SMD=-0.05；95% CI=-0.81至0.71；P = .90）或甘油三酯（SMD=-0.14；95% CI=-0.86至0.58；P = .70）没有影响：维生素D-钙补充剂可有效改善妊娠糖尿病患者的代谢状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecological Endocrinology 医学-妇产科学

CiteScore

4.40

自引率

5.00%

发文量

137

审稿时长

3-6 weeks

期刊介绍： Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction