Study of a precise treatment protocol for patients with consciousness disorders based on the brain network analysis of functional magnetic resonance imaging.

IF 3.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Neuroscience Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI:10.3389/fnins.2024.1443478

Pingzhi Wang, Jie Xiang, Yan Niu, Jing Wei, Caiqin Lan, Xiangping Li, Liying Xu, Yajie Yin, Hongxiong Wang, Tao Zhang, Lei Yang, Hao Xing, Shasha Fan, Qing Niu, Huicong Kang, Ying Liang

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引用次数: 0

Abstract

Objective: How to conduct objective and accurate individualized assessments of patients with disorders of consciousness (DOC) and carry out precision rehabilitation treatment technology is a major rehabilitation problem that needs to be solved urgently.

Methods: In this study, a multi-layer brain network was constructed based on functional magnetic resonance imaging (fMRI) to analyze the structural and functional brain networks of patients with DOC at different levels and to find regulatory targets (imaging markers) with recovery potential for DOC. Then repeated transcranial magnetic stimulation (rTMS) was performed in DOC patients to clinically validate.

Results: The brain network connectivity of DOC patients with different consciousness states is different, and the most obvious brain regions appeared in the olfactory cortex and precuneus. rTMS stimulation could effectively improve the consciousness level of DOC patients and stimulate the occipital lobe (specific regions found in this study) and the dorsolateral prefrontal cortex (DLPFC), and both parts had a good consciousness recovery effect.

Conclusion: In clinical work, personalized stimulation regimen treatment combined with the brain network characteristics of DOC patients can improve the treatment effect.

查看原文本刊更多论文

基于功能磁共振成像脑网络分析的意识障碍患者精确治疗方案研究。

目的：如何对意识障碍（DOC）患者进行客观、准确的个体化评估，开展精准康复治疗技术，是亟待解决的重大康复难题：本研究基于功能磁共振成像（fMRI）构建多层脑网络，从不同层面分析DOC患者的脑结构和功能网络，寻找对DOC具有康复潜能的调控靶点（成像标志物）。然后对 DOC 患者进行重复经颅磁刺激（rTMS），以进行临床验证：rTMS刺激可有效改善DOC患者的意识水平，刺激枕叶（本研究发现的特定区域）和背外侧前额叶皮层（DLPFC），两部分均有良好的意识恢复效果：在临床工作中，结合DOC患者的脑网络特征进行个性化刺激方案治疗，可提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroscience NEUROSCIENCES-

CiteScore

6.20

自引率

4.70%

发文量

2070

审稿时长

14 weeks

期刊介绍： Neural Technology is devoted to the convergence between neurobiology and quantum-, nano- and micro-sciences. In our vision, this interdisciplinary approach should go beyond the technological development of sophisticated methods and should contribute in generating a genuine change in our discipline.