Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization.

IF 2.3 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI:10.1080/17474086.2024.2410009

Yan-Yan Rong, Peng-Cheng Liu, Xian-Bao Huang, Guo-An Chen

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引用次数: 0

Abstract

Background: To explore the genetic causal association between lymphoma and the circulating levels of vitamins through Mendelian randomization (MR).

Research design and methods: We performed MR analysis using publicly available genome-wide association study (GWAS) summary data. Seven indicators related to the circulating levels of vitamins (vitamin D, vitamin C, vitamin B6, vitamin B12, folic acid, vitamin E, and carotene) served as exposures, while lymphoma was the outcome. The genetic causal association between these circulating levels of vitamin indicators and lymphoma was assessed using the inverse variance weighted (IVW) method.

Results: Based on IVW method, vitamin B12 (OR = 0.48; 95% CI: 0.28-5.19; p = 0.018) and folic acid (OR = 0.62; 95% CI: 0.40-0.96; p = 0.032) both showed substantial evidence of a relationship with lymphoma. Moreover, the Weighted median method similarly indicated potential evidence of an association between vitamin B12 (OR = 0.40; 95% CI: 0.18-0.90; p = 0.027) and lymphoma. The Simple mode, and Weighted mode methods showed no potential genetic causal association (p > 0.05 in the two analyses).

Conclusions: This study suggests a potential association between folic acid and vitamin B12 and lymphoma. Further research is required to assess the reproducibility of this finding in different contexts and to gain deeper insights into the potential underlying mechanisms.

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循环中的维生素水平与淋巴瘤风险：从双样本孟德尔随机试验中获得的启示。

研究背景通过孟德尔随机化（MR）探讨淋巴瘤与循环中维生素水平之间的遗传因果关系：我们利用公开的全基因组关联研究（GWAS）汇总数据进行了MR分析。与维生素循环水平相关的七个指标（维生素 D、维生素 C、维生素 B6、维生素 B12、叶酸、维生素 E 和胡萝卜素）作为暴露因子，淋巴瘤作为结果因子。采用逆方差加权法（IVW）评估了这些循环维生素指标水平与淋巴瘤之间的遗传因果关系：结果：根据 IVW 方法，维生素 B12（OR = 0.48；95% CI：0.28-5.19；p = 0.018）和叶酸（OR = 0.62；95% CI：0.40-0.96；p = 0.032）均显示出与淋巴瘤关系的实质性证据。此外，加权中值法同样显示出维生素 B12（OR = 0.40；95% CI：0.18-0.90；p = 0.027）与淋巴瘤之间存在潜在联系的证据。简单模式和加权模式方法均未显示出潜在的遗传因果关系（两项分析的 p > 0.05）：本研究表明，叶酸和维生素 B12 与淋巴瘤之间存在潜在关联。需要进一步研究，以评估这一发现在不同情况下的可重复性，并深入了解潜在的内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.