The synthesis and bioactivity of apigenin derivatives

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-09-25 DOI:10.1016/j.fitote.2024.106228

Shun Liu , Xing Zheng , Zhongqin Luo , Caihong Tang , Yufei Hu , Qingying Peng , Pengbing Mi , Hongfei Chen , Xu Yao

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引用次数: 0

Abstract

Background

Apigenin, a naturally occurring compound with a flavone core structure, is known for its diverse bioactivities, including anti-inflammation, anti-toxicant, anti-cancer and so on. There has been significant interest in the medicinal chemistry community. To address these challenges, researchers have developed various derivatives of apigenin to address challenges such as poor water-solubility and low intestinal absorption, aiming to enhance the pharmacological activities and pharmacokinetic properties of this compound.

Objective

In recent years, there has been a proliferation of apigenin derivatives with enhanced bioactivity. However, there is a lack of comprehensive reviews on the function-based modification of these derivatives. In this paper, we provide an overview of the apigenin derivatives with varying bioactivities and explored their structure activity relationships. And the functions of different groups of apigenin derivatives were also analyzed.

Conclusion

This review summarized the current achievements that could provide some clues for further study of apigenin-based drugs.

Abstract Image

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芹菜素衍生物的合成和生物活性。

背景：芹菜素是一种以黄酮为核心结构的天然化合物，具有抗炎、抗毒、抗癌等多种生物活性。这引起了药物化学界的极大兴趣。针对芹菜素水溶性差、肠道吸收率低等难题，研究人员开发了多种芹菜素衍生物，旨在提高该化合物的药理活性和药代动力学特性：近年来，生物活性更强的芹菜素衍生物层出不穷。目的：近年来，具有增强生物活性的芹菜素衍生物层出不穷，但缺乏对这些衍生物进行基于功能修饰的全面综述。本文概述了具有不同生物活性的芹菜素衍生物，并探讨了它们的结构活性关系。结论：本综述总结了目前所取得的成就，可为进一步研究芹菜苷类药物提供一些线索。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.