Geographical disparities in fibromyalgia severity: An Italian study.

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY
Marco Di Carlo, Sonia Farah, Fabiola Atzeni, Alessandra Alciati, Manuela Di Franco, Cristina Iannuccelli, Laura Bazzichi, Gerolamo Bianchi, Massimo Giovale, Rosella Tirri, Serena Guiducci, Giuliana Guggino, Franco Franceschini, Rosario Foti, Alberto Lo Gullo, Giovanni Biasi, Elisa Gremese, Lorenzo Dagna, Enrico Tirri, Roberto Giacomelli, Alberto Batticiotto, Maurizio Cutolo, Piercarlo Sarzi-Puttini, Fausto Salaffi
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引用次数: 0

Abstract

Background: Geographic origin may represent a variable capable of influencing health status. This study aims to investigate the presence of differences of disease severity in Italian patients with fibromyalgia from different macro-regions.

Methods: This retrospective, cross-sectional study involved patients included in the Italian Fibromyalgia Registry. Three geographical macro-regions were identified, comprising patients from Northern Italy, Central Italy and Southern Italy. Clinical differences (evaluated through PolySymptomatic Distress Scale [PSD], revised Fibromyalgia Impact Questionnaire [FIQR] and modified Fibromyalgia Assessment Status [FASmod]) among the geographical macro-regions were studied using one-way analysis of variance (ANOVA) and the Scheffé's test.

Results: A total of 6095 patients (5719 females and 376 males) were included, with 1957 from Northern Italy, 2979 from Central Italy and 1159 from Southern Italy. All studied clinical indices showed a trend indicative of greater disease severity in Southern Italy, followed by Northern Italy and then Central Italy (mean values for PSD: 19.97 ± 6.20 in Northern Italy, 18.61 ± 7.12 in Central Italy, 23.01 ± 5.66 in Souther Italy). These differences were statistically significant for the overall scores of all studied indices, evaluated with ANOVA (all p < 0.001) and in the head to head comparisons, evaluted with Scheffé's test.

Conclusions: Geographic background is significantly associated with variations in the severity of fibromyalgia in Italian patients.

Significance statement: This is the first study to demonstrate geographical origin-dependent intra-national differences in the severity of fibromyalgia. The results confirm the necessity of considering fibromyalgia within the context of the biopsychosocial model and of implementing healthcare policies targeted towards the most underserved regions.

纤维肌痛严重程度的地域差异:一项意大利研究。
背景:地域可能是影响健康状况的一个变量。本研究旨在调查来自不同大区的意大利纤维肌痛患者的疾病严重程度是否存在差异:这项回顾性横断面研究涉及意大利纤维肌痛登记处的患者。研究确定了三个地理大区,包括来自意大利北部、中部和南部的患者。研究采用单因素方差分析(ANOVA)和谢菲检验(Scheffé's test)对宏观地理区域之间的临床差异(通过多症状困扰量表(PSD)、修订版纤维肌痛影响问卷(FIQR)和修订版纤维肌痛评估状态(FASmod)进行评估)进行了研究:共纳入 6095 名患者(女性 5719 人,男性 376 人),其中 1957 人来自意大利北部,2979 人来自意大利中部,1159 人来自意大利南部。所有研究的临床指数都显示出一种趋势,即意大利南部的疾病严重程度更高,其次是意大利北部,然后是意大利中部(PSD 的平均值:意大利北部为 19.97 ± 6.20,意大利中部为 18.61 ± 7.12,意大利南部为 23.01 ± 5.66)。经方差分析评估,这些差异在所有研究指标的总分上都具有统计学意义(均为 p 结论):地理背景与意大利患者纤维肌痛严重程度的差异有明显关联:本研究首次证明了纤维肌痛的严重程度在不同国家间存在着与地理背景相关的差异。研究结果证实,有必要在生物心理社会模式的背景下考虑纤维肌痛,并针对服务最不充分的地区实施医疗保健政策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
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