Evgenia Papathanasiou, Georgios Kokkotis, Georgios Axiaris, Georgia Bellou, Konstantina Chalakatevaki, Angeliki Christidou, Dimitrios K Christodoulou, Kalliopi Foteinogiannopoulou, Anthia Gatopoulou, Olga Giouleme, Konstantinos Gkoumas, Maria Κalogirou, Pantelis Karatzas, Konstantinos Κarmiris, Konstantinos Κatsanos, Anastasia Κourikou, Ioannis E Κoutroubakis, Christos Liatsos, Gerassimos J Mantzaris, Nicoletta Μathou, George Michalopoulos, Aikaterini Μantaka, Penelope Nikolaou, Michael Oikonomou, George Papatheodoridis, Dimitrios Polymeros, Epameinondas Skouloudis, Konstantinos Soufleris, Evdoxia Stergiou, Aggelos Theodoulou, Angeliki Theodoropoulou, Georgios Theoxaris, Styliani Tsafaraki, Georgia Tsiolakidou, Eftychia Tsironi, Maria Tzouvala, Nikos Viazis, Spyridon Michopoulos, Giorgos Bamias, Evanthia Zampeli
{"title":"Pregnancy outcomes in Greek women with inflammatory bowel disease: a longitudinal national retrospective study.","authors":"Evgenia Papathanasiou, Georgios Kokkotis, Georgios Axiaris, Georgia Bellou, Konstantina Chalakatevaki, Angeliki Christidou, Dimitrios K Christodoulou, Kalliopi Foteinogiannopoulou, Anthia Gatopoulou, Olga Giouleme, Konstantinos Gkoumas, Maria Κalogirou, Pantelis Karatzas, Konstantinos Κarmiris, Konstantinos Κatsanos, Anastasia Κourikou, Ioannis E Κoutroubakis, Christos Liatsos, Gerassimos J Mantzaris, Nicoletta Μathou, George Michalopoulos, Aikaterini Μantaka, Penelope Nikolaou, Michael Oikonomou, George Papatheodoridis, Dimitrios Polymeros, Epameinondas Skouloudis, Konstantinos Soufleris, Evdoxia Stergiou, Aggelos Theodoulou, Angeliki Theodoropoulou, Georgios Theoxaris, Styliani Tsafaraki, Georgia Tsiolakidou, Eftychia Tsironi, Maria Tzouvala, Nikos Viazis, Spyridon Michopoulos, Giorgos Bamias, Evanthia Zampeli","doi":"10.1097/MEG.0000000000002844","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) commonly affects patients of reproductive age. The effect of disease activity on the outcome of pregnancy and its impact on neonatal health are areas of intense research.</p><p><strong>Methods: </strong>Α national retrospective study of pregnancies in women with IBD between 2010 and 2020 was carried out in 22 IBD reference centers in Greece.</p><p><strong>Results in total: </strong>223 pregnancies in 175 IBD patients [122 Crohn's disease (CD)] were included. Mean age at diagnosis was 26 years (12-44) with a mean duration of 7.4 (0-23). Pregnancy as a result of IVF occurred in 15 cases (6.7%). At the beginning of gestation, 165 patients (74%) were under treatment: 48 (29%) with anti-tumor necrosis factor alpha agents, 43 (26%) with azathioprine, 101 (61%) with 5-aminosalicylates, and 12 (7%) with steroids. Forty-nine cases (22%) of IBD flares were recorded: Two-thirds (n = 30) were in clinical remission at the onset of pregnancy, whereas treatment with corticosteroids was required in 22 (45%). Patients with ulcerative colitis were at greater risk for flare compared to those with CD (P < 0.001). All but two pregnancies (99.1%) resulted in an uncomplicated delivery. In 147 cases (67.1%), c-section was performed. Two late fetal deaths (0.9%) were reported, both in patients with persistently active disease. After delivery, 75 patients (34%) presented with a disease flare, associated with active disease at the beginning of pregnancy (P < 0.001).</p><p><strong>Conclusion: </strong>The majority of Greek patients with IBD have a favorable pregnancy outcome. Active inflammation during gestation and a diagnosis of ulcerative colitis are negatively associated with pregnancy outcomes.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MEG.0000000000002844","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
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Abstract
Background: Inflammatory bowel disease (IBD) commonly affects patients of reproductive age. The effect of disease activity on the outcome of pregnancy and its impact on neonatal health are areas of intense research.
Methods: Α national retrospective study of pregnancies in women with IBD between 2010 and 2020 was carried out in 22 IBD reference centers in Greece.
Results in total: 223 pregnancies in 175 IBD patients [122 Crohn's disease (CD)] were included. Mean age at diagnosis was 26 years (12-44) with a mean duration of 7.4 (0-23). Pregnancy as a result of IVF occurred in 15 cases (6.7%). At the beginning of gestation, 165 patients (74%) were under treatment: 48 (29%) with anti-tumor necrosis factor alpha agents, 43 (26%) with azathioprine, 101 (61%) with 5-aminosalicylates, and 12 (7%) with steroids. Forty-nine cases (22%) of IBD flares were recorded: Two-thirds (n = 30) were in clinical remission at the onset of pregnancy, whereas treatment with corticosteroids was required in 22 (45%). Patients with ulcerative colitis were at greater risk for flare compared to those with CD (P < 0.001). All but two pregnancies (99.1%) resulted in an uncomplicated delivery. In 147 cases (67.1%), c-section was performed. Two late fetal deaths (0.9%) were reported, both in patients with persistently active disease. After delivery, 75 patients (34%) presented with a disease flare, associated with active disease at the beginning of pregnancy (P < 0.001).
Conclusion: The majority of Greek patients with IBD have a favorable pregnancy outcome. Active inflammation during gestation and a diagnosis of ulcerative colitis are negatively associated with pregnancy outcomes.
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