Hyperthyroidism and hypothyroidism in patients with autoimmune pancreatitis.

IF 2.3 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI:10.1097/MEG.0000000000002846

Kenji Hirano, Katsuyuki Sanga, Hisayoshi Natomi, Kazuhiro Niwa

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引用次数: 0

Abstract

Objective: The objective of this study is to clarify the clinical features of thyroid dysfunction observed in patients with autoimmune pancreatitis (AIP).

Methods: We repeatedly examined thyroid function in 74 patients with type 1 AIP (58 males, 16 females; average onset age of AIP 67 years). Clinical and serological findings in patients with thyroid dysfunction were analyzed.

Results: During follow-up, clinical and subclinical hypothyroidism were observed in 3 and 17 patients, respectively. Clinical and subclinical hyperthyroidism were observed in 5 and 1 patients, respectively. One patient showed clinical hyperthyroidism followed by subclinical hypothyroidism. All patients with clinical and subclinical hypothyroidism were asymptomatic and required no medical treatment, whereas four patients with clinical hyperthyroidism were symptomatic and received treatment with thiamazole.

Conclusion: Frequent hypothyroidism in AIP, which was previously reported, was confirmed. Moreover, in this study, the association between hyperthyroidism and AIP was demonstrated. Hyperthyroidism in AIP may be more clinically significant than hypothyroidism because patients frequently require medical treatment.

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自身免疫性胰腺炎患者的甲状腺功能亢进症和甲状腺功能减退症。

研究目的本研究旨在阐明自身免疫性胰腺炎（AIP）患者甲状腺功能障碍的临床特征：我们对74名1型AIP患者（58名男性，16名女性；AIP平均发病年龄67岁）的甲状腺功能进行了反复检查。结果：在随访过程中，甲状腺功能障碍患者的临床和血清学结果均有所改善：结果：在随访期间，分别有 3 名和 17 名患者出现临床和亚临床甲状腺功能减退。分别有 5 名和 1 名患者出现临床和亚临床甲状腺功能亢进。一名患者先出现临床甲亢，后出现亚临床甲减。所有临床和亚临床甲状腺功能减退症患者均无症状，无需药物治疗，而4名临床甲状腺功能亢进症患者有症状，并接受了噻马唑治疗：结论：AIP患者中经常出现甲状腺功能减退，这在之前的报道中得到了证实。此外，本研究还证实了甲状腺功能亢进症与 AIP 之间的关联。甲状腺功能亢进症在AIP中的临床意义可能大于甲状腺功能减退症，因为患者经常需要接受药物治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.