Effects of carotenoid supplementation on glycemic control: a systematic review and meta-analysis of randomized clinical trials.

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS

European Journal of Clinical Nutrition Pub Date : 2024-09-26 DOI:10.1038/s41430-024-01511-y

Nafiseh Shokri-Mashhadi, Christina Baechle, Tim Schiemann, Edyta Schaefer, Janett Barbaresko, Sabrina Schlesinger

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引用次数: 0

Abstract

Objectives: We conducted a systematic review and meta-analysis to assess the effects of carotenoid supplementation on glycemic indices, and the certainty of evidence.

Methods: A systematic literature search in PubMed, SCOPUS, ISI-Web of Science, and Cochrane Library was conducted from inception up to Jun 17, 2024. Randomized controlled trials (RCTs) investigating the effect of carotenoid supplementation on circulating glycemic parameters were included. Records were excluded when studies reported the effect of co-interventions with other nutrients, did not provide mean differences (MDs) and standard deviations (SD) for outcomes, or administered whole food rather than supplements of carotenoids. Summary mean differences (MDs) and 95% CI between intervention and control groups were estimated using a random-effects model. The risk of bias of the included studies was assessed using the Risk of Bias 2.0 (RoB 2.0) tool.

Results: Overall, 36 publications with 45 estimated effect sizes were included in the meta-analyses. The overall findings showed an improvement in fasting blood glucose (FBG) (MD = -4.54 mg/dl; 95% CI: -5.9, -3.2; n = 45), and hemoglobin A1C (HbA1C) (MD = -0.25% (95% CI: -0.4, -0.11; n = 22) in the intervention group in comparison with the control group. Moreover, in individuals with type 2 diabetes (T2D), interventions with astaxanthin and fucoxanthin led to a reduction in FBG by 4.36 mg/dl (95% CI: -6.13, -2.6; n = 10). The findings also showed that the intervention with crocin reduced FBG levels by 13.5 mg/dl (95% CI: -15.5, -7.8; n = 5), and HbA_1C by 0.55% (95% CI: -0.77, -0.34; n = 5) in individuals with T2D. However, the certainty of evidence was very low.

Conclusion: Carotenoid's supplementation improved glycemic parameters especially in people with T2D. However. the certainty of evidence was very low, mainly due to small sample size, and indirectness. Therefore, no specific recommendations can be provided at present and well-designed RCTs are required. REGISTRY URL: https://www.crd.york.ac.uk/PROSPERO/ REGISTRY NUMBER: CRD42021285084 REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OR META-ANALYSES: PROSPERO ID: CRD42021285084.

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类胡萝卜素补充剂对血糖控制的影响：随机临床试验的系统回顾和荟萃分析。

目的：我们对补充类胡萝卜素对血糖指数的影响以及证据的确定性进行了系统回顾和荟萃分析：我们进行了一项系统综述和荟萃分析，以评估补充类胡萝卜素对血糖指数的影响以及证据的确定性：方法：我们在 PubMed、SCOPUS、ISI-Web of Science 和 Cochrane Library 中进行了系统性文献检索，检索时间从开始至 2024 年 6 月 17 日。纳入了研究类胡萝卜素补充剂对循环血糖参数影响的随机对照试验（RCT）。如果研究报告了与其他营养素共同干预的效果，未提供结果的平均差（MDs）和标准差（SD），或使用的是全食物而非类胡萝卜素补充剂，则排除这些记录。采用随机效应模型估算了干预组和对照组之间的平均差（MDs）和 95% CI。使用偏倚风险 2.0（RoB 2.0）工具评估了纳入研究的偏倚风险：荟萃分析共纳入了 36 篇文献，估计效应大小为 45。总体结果显示，与对照组相比，干预组的空腹血糖（FBG）（MD = -4.54 mg/dl；95% CI：-5.9，-3.2；n = 45）和血红蛋白 A1C（HbA1C）（MD = -0.25%（95% CI：-0.4，-0.11；n = 22）有所改善。此外，在2型糖尿病（T2D）患者中，使用虾青素和福柯黄素进行干预后，FBG降低了4.36毫克/分升（95% CI：-6.13，-2.6；n = 10）。研究结果还显示，使用巴豆黄素进行干预后，T2D 患者的 FBG 水平降低了 13.5 mg/dl (95% CI: -15.5, -7.8; n = 5)，HbA1C 降低了 0.55% (95% CI: -0.77, -0.34; n = 5)。然而，证据的确定性非常低：补充类胡萝卜素可改善血糖参数，尤其是对患有 T2D 的患者。结论：补充类胡萝卜素可改善血糖指标，尤其是对 T2D 患者的改善作用。然而，证据的确定性非常低，主要原因是样本量小和间接性。因此，目前还不能提供具体的建议，需要进行精心设计的 RCT 研究。注册表网址：https://www.crd.york.ac.uk/PROSPERO/ 注册表编号：CRD42021285084 系统综述或荟萃分析的注册表和注册表编号：PROSPERO ID：CRD42021285084。

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)