Evaluation of testicular volume in males with congenital hypogonadotropic hypogonadism: a comparative analysis.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2024-09-25 DOI:10.1007/s12020-024-04032-7

Konsam Biona Devi, Ujjwal Gorsi, Anupam Lal, Shubham Saini, Akhil Jerath, Dorendro Thingujam, Mintu Mani Baruah, Rama Walia

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引用次数: 0

Abstract

Introduction: Estimating accurate testicular volume (TV) of congenital hypogonadotropic hypogonadism (CHH) individuals is challenging due to the typically small testicular size. Ultrasound (USG) emerges as a vital solution, enabling precise measurements and reproducible results. The purpose of the study was to assess the three-dimensional measurement of the testis using USG and its volume was estimated using Ellipsoid (E) and Lambert (L) formulae and compared these with the TV by Prader orchidometer (OrTV).

Methods: This is an exploratory analysis of data taken from a clinical trial conducted from May 2022 to March 2024 which included 94 testes from 47 CHH participants. The OrTVs and USGTVs were assessed at baseline and every three months till the completion of the study making a total of 348 observations. The three-dimensional measurement of the testes was noted and TVs were calculated using the above formulae.

Results: The mean age of the participants was 25.8 ± 6.14 years with a mean height of 169.9 ± 8.42 cm and body mass index (BMI) of 22.4 ± 4.72 kg/m². The baseline mean OrTV, USGTV(E) and USGTV(L) were 2.15 ± 0.79 ml, 0.69 ± 0.43 ml and 0.93 ± 0.59 ml respectively. The smallest OrTV observed was 1 ml with its respective mean USGTV of 0.41 ± 0.2 ml(E) and 0.56 ± 0.27 ml(L). An OrTV of 4 ml had a mean USGTV of 1.11 ± 0.42 ml(E) and 1.51 ± 9.57 ml(L). At spermatogenesis, the mean OrTV was 8.84 ± 3.13 ml with the USGTV determined to be 4 ± 1.46 ml(E) and 5.46 ± 1.99 ml(L).

Conclusion: The study revealed that all CHH patients at diagnosis had OrTV < 4 ml. This corresponds to a USG TV cut-off of 1.11 ml using the Ellipsoid formula and 1.51 ml with the Lambert formula, which could serve as a USG diagnostic criterion for CHH.

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评估先天性性腺功能减退症男性的睾丸体积：对比分析。

简介：由于先天性性腺功能减退症（CHH）患者的睾丸通常较小，因此准确估计其睾丸体积（TV）是一项挑战。超声波（USG）是一种重要的解决方案，可实现精确测量和结果的可重复性。本研究的目的是使用 USG 评估睾丸的三维测量结果，使用椭圆体（E）和兰伯特（L）公式估算睾丸体积，并与普拉德睾丸测量仪（OrTV）进行比较：这是对 2022 年 5 月至 2024 年 3 月进行的一项临床试验数据的探索性分析，该试验包括 47 名 CHH 参与者的 94 个睾丸。对 OrTV 和 USGTV 进行了基线评估和每三个月一次的评估，直至研究结束，共进行了 348 次观察。研究人员记录了睾丸的三维测量结果，并使用上述公式计算了TV值：参与者的平均年龄为（25.8±6.14）岁，平均身高为（169.9±8.42）厘米，体重指数（BMI）为（22.4±4.72）千克/平方米。基线平均 OrTV、USGTV(E) 和 USGTV(L) 分别为 2.15 ± 0.79 毫升、0.69 ± 0.43 毫升和 0.93 ± 0.59 毫升。观察到的最小 OrTV 为 1 毫升，其平均 USGTV 分别为 0.41 ± 0.2 毫升（E）和 0.56 ± 0.27 毫升（L）。4 毫升 OrTV 的平均 USGTV 为 1.11 ± 0.42 毫升（东）和 1.51 ± 9.57 毫升（长）。精子发生时，OrTV的平均值为8.84 ± 3.13 ml，USGTV的平均值为4 ± 1.46 ml（E）和5.46 ± 1.99 ml（L）：研究显示，所有 CHH 患者在确诊时的 OrTV

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.