Hepatoprotective potentials of Usnea longissima Ach. and Xanthoparmelia somloensis (Gyelnik) Hale extracts in ethanol-induced liver injury.

IF 2.1 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Drug and Chemical Toxicology Pub Date : 2024-09-25 DOI:10.1080/01480545.2024.2407867

Mehmet Berköz, Ali Aslan, Oruç Yunusoğlu, Mirosław Krośniak, Renata Francik

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引用次数: 0

Abstract

In our study, the antioxidant and anti-inflammatory effects of different lichen applications were investigated in rats using an experimental ethanol toxicity model. 48 rats were used in the study and they were divided into 6 groups with 8 rats in each group. These groups were: control, ethanol (2 g/kg), ethanol + Usnea longissima Ach. (200 mg/kg), ethanol + Usnea longissima Ach. (400 mg/kg), ethanol + Xanthoparmelia somloensis (Gyelnik) Hale (100 mg/kg) and ethanol + Xanthoparmelia somloensis (Gyelnik) Hale (200 mg/kg). The experimental work continued for 21 days. Lichen extracts and ethanol were administered by gavage to rats divided into groups. According to the experimental protocol, the experimental animals were sacrificed and their liver tissues were isolated. Biochemical parameters in serum, histological examinations, oxidative stress and inflammation parameters both at biochemical and molecular level in liver tissues were performed. Oxidative stress and inflammatory response were increased in the liver tissue of rats treated with ethanol for 21 days, and liver functions were impaired. It was found that U. longissima and X. somloensis extracts showed good antioxidant activity and conferred protective effects against ethanol-induced oxidative stress and inflammation. This could be attributed to the presence of secondary metabolites in the extract, which act as natural antioxidants and could be responsible for increasing the defence mechanisms against free radical production induced by ethanol administration.

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Usnea longissima Ach.和 Xanthoparmelia somloensis (Gyelnik) Hale 提取物在乙醇诱导的肝损伤中的保肝潜力。

在我们的研究中，我们利用乙醇毒性实验模型，研究了不同地衣应用对大鼠的抗氧化和抗炎作用。48 只大鼠被分成 6 组，每组 8 只。这些组分别为：对照组、乙醇组（2 克/千克）、乙醇 + Usnea longissima Ach.(200 毫克/千克）、乙醇 + Usnea longissima Ach.(400 mg/kg)、乙醇 + Xanthoparmelia somloensis (Gyelnik) Hale (100 mg/kg) 和乙醇 + Xanthoparmelia somloensis (Gyelnik) Hale (200 mg/kg)。实验工作持续了 21 天。地衣提取物和乙醇以灌胃方式给大鼠分组。按照实验方案，实验动物被处死，并分离其肝脏组织。对肝组织的血清生化指标、组织学检查、氧化应激和炎症指标进行了生化和分子水平的检测。结果表明，乙醇处理 21 天的大鼠肝组织中氧化应激和炎症反应增加，肝功能受损。研究发现，U. longissima 和 X. somloensis 提取物具有良好的抗氧化活性，对乙醇引起的氧化应激和炎症反应具有保护作用。这可能是因为萃取物中含有次生代谢物，这些次生代谢物是天然的抗氧化剂，可以增强对乙醇诱导的自由基产生的防御机制。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.