Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study.

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Nicolas Richard, Ariane Leroyer, Delphine Ley, Claire Dupont, Valérie Bertrand, Pauline Wils, Corine Gower-Rousseau, Dominique Turck, Nathalie Guillon, Hélène Sarter, Guillaume Savoye, Mathurin Fumery
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引用次数: 0

Abstract

Introduction: Patients with inflammatory bowel disease (IBD) are at higher risk of thromboembolic events (TE). In pediatric-onset IBD, more data on incidence and risk factors of venous (VTE) and arterial events (ATE) at the population level are needed to guide thromboprophylaxis.

Methods: All patients aged ≤ 16 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between 1988 and 2011 in the prospective EPIMAD population-based registry were followed until 2013. Every TE occurring during the follow-up period was included.

Results: A total of 1,344 patients were included: 1,007 with CD and 337 with UC, and a median diagnosis age of 14.3 years. After a median follow-up of 8.3 years, 2 (0.15 %) ATE and 15 (1.1 %) VTE occurred at median age of 20.4 years. The global incidence rate of thromboembolic events was 1.32 per 1000 person-years. Periods of active disease (HR=8.4, p = 0.0002), the 3-month-period following surgery (HR=16.4, p = 0.0002) and hospitalization (HR=21.7, p < 0.0001) were found to be associated with an increased risk of VTE. A lower rate of VTE was found in patients treated with 5-aminosalicylates (HR=0.1, p = 0.002).

Conclusion: The risk of TE was low in this population. VTE were strongly associated with active disease, surgery and hospitalization.

儿科炎症性肠病血栓栓塞事件的发生率和风险因素:一项基于法国人口的研究。
导言:炎症性肠病(IBD)患者发生血栓栓塞事件(TE)的风险较高。在小儿IBD患者中,需要更多关于静脉(VTE)和动脉事件(ATE)发生率和风险因素的数据,以指导血栓预防:方法:对1988年至2011年间在前瞻性EPIMAD人群登记中确诊为克罗恩病(CD)或溃疡性结肠炎(UC)的所有年龄≤16岁的患者进行随访,直至2013年。随访期间发生的所有TE均被纳入:结果:共纳入 1,344 名患者:结果:共纳入 1,344 名患者:1,007 名 CD 患者和 337 名 UC 患者,中位诊断年龄为 14.3 岁。中位随访 8.3 年后,2 例(0.15%)ATE 和 15 例(1.1%)VTE 发生,中位年龄为 20.4 岁。血栓栓塞事件的总体发病率为每千人年 1.32 例。活动期(HR=8.4,p = 0.0002)、术后 3 个月(HR=16.4,p = 0.0002)和住院期(HR=21.7,p < 0.0001)与 VTE 风险增加有关。使用5-氨基水杨酸盐治疗的患者VTE发生率较低(HR=0.1,P=0.002):结论:在这一人群中,TE 的风险较低。VTE与活动性疾病、手术和住院密切相关。
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来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
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