12-Month Time in Tight Range Improvement with Advanced Hybrid-Closed Loop System in Adults with Type 1 Diabetes.

IF 3.8 3区医学 Q2 Medicine

Diabetes Therapy Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI:10.1007/s13300-024-01656-w

Laura Nigi, Maria De Los Angeles Simon Batzibal, Dorica Cataldo, Francesco Dotta

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Abstract

Introduction: Time in tight range (TITR) is an emerging and valuable metric for assessing normoglycemia. The latest advancement in automated insulin delivery (AID) systems, the advanced hybrid closed-loop (AHCL) systems, are particularly noteworthy for managing type 1 diabetes (T1D) and enhancing glycemic control.

Methods: In a real-world clinical setting, we carried out a retrospective evaluation of TITR in 42 adult subjects with T1D using the AHCL Minimed™ 780G system over a 12-month period.

Results: Within just 14 days of activating the automatic mode, the AHCL Minimed™ 780G system showed rapid improvement in TITR, and in the other continuous glucose monitoring (CGM) metrics. This improvement persisted over 12 months, achieving the proposed 45-50% range for effective glycemic control.

Conclusion: The AHCL Minimed™ 780G system significantly enhances TITR, demonstrating continuous improvement throughout a 12-month follow-up period.

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在 1 型糖尿病成人患者中使用先进的混合闭环系统，12 个月后拮抗范围有所改善。

导言胰岛素紧控时间（TITR）是评估血糖正常与否的一个新兴且有价值的指标。胰岛素自动给药系统（AID）的最新进展--高级混合闭环系统（AHCL）在管理 1 型糖尿病（T1D）和加强血糖控制方面尤其值得关注：在真实的临床环境中，我们使用 AHCL Minimed™ 780G 系统对 42 名患有 T1D 的成年受试者进行了为期 12 个月的 TITR 回顾性评估：结果：在激活自动模式的短短 14 天内，AHCL Minimed™ 780G 系统的 TITR 和其他连续血糖监测 (CGM) 指标都有了迅速改善。这种改善持续了 12 个月，达到了建议的 45-50% 有效血糖控制范围：结论：AHCL Minimed™ 780G 系统显著提高了 TITR，在 12 个月的随访期间持续改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.