The Effect of Platelet Dose on Outcomes after Platelet Rich Plasma Injections for Musculoskeletal Conditions: A Systematic Review and Meta-Analysis.

IF 2.9 2区医学 Q1 ORTHOPEDICS

Current Reviews in Musculoskeletal Medicine Pub Date : 2024-09-27 DOI:10.1007/s12178-024-09922-x

William Berrigan, Frances Tao, Joel Kopcow, Anna L Park, Isabel Allen, Peggy Tahir, Aakash Reddy, Zachary Bailowitz

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引用次数: 0

Abstract

Purpose of review: This study aims to systematically review platelet dosage in platelet rich plasma (PRP) injections for common musculoskeletal conditions.

Recent findings: Notable heterogeneity exists in the literature regarding platelet dosage. Clinical studies indicate that a higher dosage may lead to improved outcomes concerning pain relief, functional improvement, and chondroprotection in knee osteoarthritis (OA). However, the impact of dosing on other musculoskeletal pathologies remains uncertain. Our investigation identifies a potential dose-response relationship between platelet dose and PRP effectiveness for knee OA treatment, pinpointing an optimal threshold of greater than 10 billion platelets for favorable clinical outcomes. Notably, this effect appears more pronounced for functional outcomes than for pain relief. For other conditions, a lower dosage may suffice, although the existing literature lacks clarity on this matter. PRP dosage may significantly influence treatmentoutcomes, particularly in knee OA. Further research is warranted to elucidate optimal dosages for varying conditions.

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血小板剂量对富血小板血浆注射治疗肌肉骨骼疾病后疗效的影响：系统回顾与元分析》。

综述目的：本研究旨在系统回顾富血小板血浆（PRP）注射治疗常见肌肉骨骼疾病的血小板用量：有关血小板用量的文献存在明显的异质性。临床研究表明，在膝关节骨性关节炎（OA）中，较高的剂量可改善疼痛缓解、功能改善和软骨保护效果。然而，剂量对其他肌肉骨骼病症的影响仍不确定。我们的研究发现，血小板剂量与 PRP 治疗膝关节 OA 的效果之间存在潜在的剂量-反应关系，确定了超过 100 亿个血小板的最佳阈值，以获得良好的临床效果。值得注意的是，这种效应对功能性结果的影响似乎比对疼痛缓解的影响更明显。对于其他病症，较低的剂量可能就足够了，尽管现有文献对此并不清楚。PRP 的用量可能会对治疗结果产生重大影响，尤其是在膝关节 OA 中。有必要进一步研究，以阐明不同情况下的最佳剂量。

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来源期刊

Current Reviews in Musculoskeletal Medicine ORTHOPEDICS-

CiteScore

7.50

自引率

2.40%

发文量

期刊介绍： This journal intends to review the most significant recent developments in the field of musculoskeletal medicine. By providing clear, insightful, balanced contributions by expert world-renowned authors, the journal aims to serve all those involved in the diagnosis, treatment, management, and prevention of musculoskeletal-related conditions. We accomplish this aim by appointing authorities to serve as Section Editors in key subject areas, such as rehabilitation of the knee and hip, sports medicine, trauma, pediatrics, health policy, customization in arthroplasty, and rheumatology. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 20 diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.