Chitosan-Peptide Composites for Tissue Engineering Applications: Advances in Treatment Strategies.

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Swati Gupta Sanjaykumar, Rishabha Malviya, Saurabh Srivastava, Irfan Ahmad, Prerna Uniyal, Bhupinder Singh, Nazima Nisar
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引用次数: 0

Abstract

One of the most well-known instances of an interdisciplinary subject is tissue engineering, where experts from many backgrounds collaborate to address important health issues and improve people's quality of life. Many researchers are interested in using chitosan and its derivatives as an alternative to fabricating scaffold engineering and skin grafts in tissue because of its natural abundance, affordability, biodegradability, biocompatibility, and wound healing properties. Nanomaterials based on peptides can provide cells with the essential biological cues required to promote cellular adhesion and are easily fabricated. Due to such worthy properties of chitosan and peptide, they find their application in tissue engineering and regeneration processes. The implementation of hybrids of chitosan and peptide is increasing in the field of tissue engineering and scaffolding for improved cellular adherence and bioactivity. This review covers the individual applications of peptide and chitosan in tissue engineering and further discusses the role of their conjugates in the same. Here, the recent findings are also discussed, along with studies involving the use of these hybrids in tissue engineering applications.

用于组织工程应用的壳聚糖-肽复合材料:治疗策略的进展。
组织工程学是最著名的跨学科课题之一,来自不同背景的专家通过合作解决重要的健康问题,提高人们的生活质量。壳聚糖及其衍生物天然丰富、价格低廉、可生物降解、具有生物相容性和伤口愈合特性,因此许多研究人员对使用壳聚糖及其衍生物作为制造组织支架工程和皮肤移植的替代品很感兴趣。基于肽的纳米材料可以为细胞提供促进细胞粘附所需的基本生物线索,而且易于制造。由于壳聚糖和肽具有如此重要的特性,它们在组织工程和再生过程中得到了应用。为了提高细胞粘附性和生物活性,壳聚糖和肽混合物在组织工程和支架领域的应用日益增多。本综述介绍了多肽和壳聚糖在组织工程中的应用,并进一步讨论了它们的共轭物在组织工程中的作用。本文还讨论了最近的研究成果,以及在组织工程应用中使用这些混合物的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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