Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen

IF 4.8 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2024-09-27 DOI:10.1111/cod.14696

V. Marmgren, M. Mowitz, E. Zimerson, M. Hindsén, M. Bruze

{"title":"Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen","authors":"V. Marmgren, M. Mowitz, E. Zimerson, M. Hindsén, M. Bruze","doi":"10.1111/cod.14696","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Photoallergic reactions due to topical ketoprofen are common. As some simultaneous contact allergies have been described in the literature, we aimed to get an overview of the pattern of reactivity towards common allergens in the baseline series in ketoprofen-photoallergic individuals.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Using our database, we found 94 patients with photocontact allergy to ketoprofen diagnosed during 1999–2018. Approximately 12 800 patients patch tested with the baseline series during the same time frame served as controls. Data on patch testing with the baseline series of 518 individuals belonging to the general population were obtained from an earlier study, and a comparison of allergy rates was made with the ketoprofen group.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Contact allergy to fragrance mix I and <i>Myroxylon pereirae</i> was overrepresented among patients with photocontact allergy to ketoprofen (42.3% vs. 6.6% and 47.9% vs. 6.6%, <i>p</i> < 0.001, respectively). Significant overrepresentation was also shown for 4-tert-butylphenolformaldehyde resin (PTBP-F-R), phenol formaldehyde resin (PFR-2), black rubber mix, budesonide (all <i>p</i> < 0.001), and fragrance mix II (<i>p</i> = 0.02). The pattern was similar, but with lower significance levels for fragrance mix II and budesonide, regardless of whether or not the individuals had been photopatch tested because of a suspected photoallergic contact dermatitis from ketoprofen.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Contact allergy to fragrance mix I, <i>Myroxylon pereirae</i>, black rubber mix, PFR-2, PTBP-FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non-related, substances.</p>\n </section>\n </div>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":"91 6","pages":"474-484"},"PeriodicalIF":4.8000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cod.14696","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact Dermatitis","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cod.14696","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Photoallergic reactions due to topical ketoprofen are common. As some simultaneous contact allergies have been described in the literature, we aimed to get an overview of the pattern of reactivity towards common allergens in the baseline series in ketoprofen-photoallergic individuals.

Methods

Using our database, we found 94 patients with photocontact allergy to ketoprofen diagnosed during 1999–2018. Approximately 12 800 patients patch tested with the baseline series during the same time frame served as controls. Data on patch testing with the baseline series of 518 individuals belonging to the general population were obtained from an earlier study, and a comparison of allergy rates was made with the ketoprofen group.

Results

Contact allergy to fragrance mix I and Myroxylon pereirae was overrepresented among patients with photocontact allergy to ketoprofen (42.3% vs. 6.6% and 47.9% vs. 6.6%, p < 0.001, respectively). Significant overrepresentation was also shown for 4-tert-butylphenolformaldehyde resin (PTBP-F-R), phenol formaldehyde resin (PFR-2), black rubber mix, budesonide (all p < 0.001), and fragrance mix II (p = 0.02). The pattern was similar, but with lower significance levels for fragrance mix II and budesonide, regardless of whether or not the individuals had been photopatch tested because of a suspected photoallergic contact dermatitis from ketoprofen.

Conclusion

Contact allergy to fragrance mix I, Myroxylon pereirae, black rubber mix, PFR-2, PTBP-FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non-related, substances.

Abstract Image

查看原文本刊更多论文

对酮洛芬光接触过敏患者进行基线系列贴片测试的结果令人惊讶。

目的：外用酮洛芬引起的光过敏反应很常见。由于文献中描述了一些同时发生的接触过敏，我们旨在了解酮洛芬光过敏者基线系列中对常见过敏原的反应模式：通过我们的数据库，我们找到了在 1999-2018 年期间确诊的 94 名对酮洛芬光接触过敏的患者。在同一时期，约有 12 800 名患者接受了基线系列贴片测试作为对照。早前的一项研究获得了518名普通人群的基线系列贴片测试数据，并与酮洛芬组的过敏率进行了比较：结果：在对酮洛芬光接触过敏的患者中，对混合香料 I 和麝香草酚接触过敏的比例较高（42.3% 对 6.6%，47.9% 对 6.6%，p 结论：对酮洛芬光过敏的患者中，对混合香料 I、佩兰 Myroxylon pereirae、黑橡胶混合香料、PFR-2、PTBP-FR 接触过敏的比例较高，对混合香料 II 和布地奈德接触过敏的比例较低。对酮洛芬过敏是否会导致对其他一些化学上不相关的物质同时过敏，还有待观察。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".