Prognostic Value of Murray Law-Based QFR (μQFR)-Guided Virtual PCI in Patients With Physiological Ischemia.

IF 6.1 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation: Cardiovascular Interventions Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI:10.1161/CIRCINTERVENTIONS.124.014362

Lianglong Chen, Yuanming Yan, Jiaxin Zhong, Ping Chen, Wei Chen, Chaoxiang Xu, Long Chen, Shengxian Tu, Yukun Luo

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引用次数: 0

Abstract

Background: Quantitative flow ratio (QFR)-based virtual percutaneous coronary intervention (PCI) is associated with improved post-PCI physiological results. Murray law-based QFR (μQFR) is a new method for physiological assessment that has higher feasibility and efficiency. The purpose of this study was to investigate the performance of μQFR-guided virtual PCI in improving post-PCI outcomes.

Methods: The QUITE RIGHT study (Quantitative Flow Ratio Virtual Stenting and Angiography Guided Percutaneous Coronary Intervention) is a prospective, multicenter, blinded, randomized, controlled superiority study. Eligible patients were randomized 1:1 to either the μQFR-guided virtual PCI group or the angiography-guided PCI group. The primary end point was the proportion of the target vessels with a post-PCI μQFR ≥0.90, accepted as an optimal post-PCI physiological outcome.

Results: A total of 622 patients with 666 vessels were enrolled. The optimal physiological outcome was reached more often in the μQFR-guided virtual PCI group (absolute difference, 9.1% [95% CI, 4.53-13.76]; P<0.001). The μQFR-guided virtual PCI group had a better QFR value, a lower contrast agent dose and x-ray dose, and a more appropriate stent length than the angiography-guided group.

Conclusions: The QUITE RIGHT study showed that the μQFR-guided virtual PCI strategy is superior to angiography-guided PCI in terms of physiological outcomes. The μQFR-guided virtual PCI strategy is associated with lower contrast and x-ray doses and a more appropriate stent length.

Registration: URL: https://www.chictr.org.cn/; Unique identifier: ChiCTR2100045452.

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基于 Murray Law 的 QFR (μQFR) 引导的虚拟 PCI 对生理性缺血患者的预后价值。

背景：基于定量血流比（QFR）的虚拟经皮冠状动脉介入治疗（PCI）可改善PCI后的生理结果。基于 Murray 法的 QFR（μQFR）是一种新的生理评估方法，具有更高的可行性和效率。本研究旨在探讨μQFR引导的虚拟PCI在改善PCI术后结果方面的性能：QUITE RIGHT 研究（定量血流比虚拟支架和血管造影引导的经皮冠状动脉介入治疗）是一项前瞻性、多中心、盲法、随机对照的优越性研究。符合条件的患者按 1:1 随机分配到μQFR 引导的虚拟 PCI 组或血管造影引导的 PCI 组。主要终点是PCI后μQFR≥0.90的靶血管比例，这是PCI后的最佳生理结果：结果：共有 622 名患者、666 根血管参与了这项研究。μQFR引导的虚拟PCI组更容易达到最佳生理结果（绝对差异为9.1% [95% CI, 4.53-13.76]；PC结论：QUITE RIGHT 研究表明，就生理结果而言，μQFR 引导的虚拟 PCI 策略优于血管造影引导的 PCI。μQFR引导的虚拟PCI策略与较低的造影剂和X射线剂量以及更合适的支架长度有关：URL: https://www.chictr.org.cn/; Unique identifier：ChiCTR2100045452。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation: Cardiovascular Interventions CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

10.30

自引率

1.80%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Circulation: Cardiovascular Interventions, an American Heart Association journal, focuses on interventional techniques pertaining to coronary artery disease, structural heart disease, and vascular disease, with priority placed on original research and on randomized trials and large registry studies. In addition, pharmacological, diagnostic, and pathophysiological aspects of interventional cardiology are given special attention in this online-only journal.