Pulsed-Field Ablation in Management of Ventricular Tachycardia: A Systematic Review of Case Reports and Clinical Outcomes

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-01 DOI:10.1002/clc.70018

Amir Askarinejad, Erfan Kohansal, Amirreza Sabahizadeh, Hamed Hesami, Sara Adimi, Majid Haghjoo

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Abstract

Background

Pulsed-field ablation (PFA) is a cutting-edge technique that employs non-thermal energy to cause cell death by inducing irreversible electroporation of cell membranes. This systematic review evaluates the PFA effectiveness as a potential alternative to radiofrequency and cryo-ablation for treating ventricular tachycardia.

Methods

PubMed, Embase, Scopus, and Web of Science were systematically searched using keywords related to ventricular tachycardia and pulsed-field ablation. Eligible Studies evaluating this therapeutic approach for ventricular tachycardia were included in the final analysis.

Results

We included six studies (five case reports and one case series) in our systematic review. Eight (88.8%) of procedures were successful with 100% long-term efficacy. No procedural complications or ventricular tachycardia (VT) recurrence were observed in the cases.

Conclusion

The absence of complications, high effectiveness, and long-term success rate make PFAs a good VT treatment option. However, PFA safety and efficacy studies for VT treatment are scarce. Thus, larger investigations on this topic are urgently needed.

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脉冲场消融治疗室性心动过速：病例报告和临床结果的系统回顾。

背景：脉冲场消融术（PFA）是一种尖端技术，它利用非热能量通过诱导细胞膜的不可逆电穿孔而导致细胞死亡。本系统综述评估了射频场消融作为射频和冷冻消融治疗室性心动过速的潜在替代方法的有效性：使用与室速和脉冲场消融相关的关键词对 PubMed、Embase、Scopus 和 Web of Science 进行了系统检索。最终分析纳入了评估这种室性心动过速治疗方法的合格研究：我们在系统回顾中纳入了六项研究（五项病例报告和一项系列病例）。其中八项（88.8%）手术成功，长期疗效达 100%。这些病例均未出现手术并发症或室性心动过速（VT）复发：结论：PFA 无并发症、疗效高、长期成功率高，是治疗 VT 的良好选择。然而，PFA 治疗 VT 的安全性和有效性研究还很少。因此，迫切需要对这一课题进行更大规模的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464