Risk and determinants of sarcopenia in people with diabetes: a case-control study from Qatar Biobank cohort.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Hibeh Shatila, Nour Ghazal, Ghalya Bukshaisha, Shaikha Al-Zeyara, Cosette Fakih El Khoury, Maya Bassil
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Abstract

Background: Diabetes is associated with impairments in muscle mass and quality increasing the risk of sarcopenia. Thus, this study aimed to investigate the odds of sarcopenia and its associated risk factors among Qatari adults (> 18 years), while exploring the modulating effects of health and lifestyle factors.

Methods: Using a case-control design, data from 767 participants (481 cases with diabetes and 286 controls without diabetes) was collected from Qatar Biobank (QBB). Sociodemographic, lifestyle factors including dietary intake, anthropometric and biochemical measures were analyzed. Handgrip strength, Dual X-ray absorptiometry (DXA), and Bio-impedance were used to assess muscle strength, muscle mass and muscle quality, respectively. The risk of sarcopenia was estimated using the European consensus on definition and diagnosis of sarcopenia.

Results: Cases with diabetes were older (55 vs. 36 years; P < 0.001), had higher BMI (31.6 vs. 28.3 kg/m2; P < 0.001), lower cardiorespiratory fitness (50.0% "Moderate" fitness for cases, 62.9% "High" fitness for controls), and consumed less total (59.0 vs. 64.0; P = 0.004) and animal protein (39.0 vs. 42.0; P = 0.001), compared to controls based on a computed score. Participants with diabetes also had lower appendicular lean mass/BMI, handgrip strength, and higher probability of sarcopenia/probable sarcopenia (P < 0.005). Adjusted multiple logistic regression revealed that elevated cardiorespiratory fitness (β = 0.299, 95%CI:0.12-0.74) and blood triglycerides (β = 1.475, 95% CI: 1.024-2.124), as well as being a female (β = 0.086, 95%CI: 0.026-0.288) and having higher BMI (β = 0.908, 95%CI: 0.852-0.967) and ALM/BMI (β = 0.000, 95% CI: 0.000-0.007) are independent predictors (p < 0.05) of sarcopenia risk.

Conclusions: This study highlights the intricate relationship between diabetes and sarcopenia, revealing modifiable risk factors. Individuals with diabetes were found to have a higher likelihood of sarcopenia, which was associated with lower fitness levels and higher blood triglycerides. Protective factors against sarcopenia included being female and having higher BMI and ALM/BMI ratios.

糖尿病患者患肌肉疏松症的风险和决定因素:一项来自卡塔尔生物库队列的病例对照研究。
背景:糖尿病与肌肉质量和质量受损有关,会增加患肌肉疏松症的风险。因此,本研究旨在调查卡塔尔成年人(18 岁以上)患肌肉疏松症的几率及其相关风险因素,同时探讨健康和生活方式因素的调节作用:采用病例对照设计,从卡塔尔生物库(Qatar Biobank,QBB)中收集了 767 名参与者(481 名糖尿病患者和 286 名非糖尿病对照者)的数据。对社会人口学、生活方式因素(包括饮食摄入量)、人体测量和生化指标进行了分析。手握力、双 X 射线吸收测量(DXA)和生物阻抗分别用于评估肌肉力量、肌肉质量和肌肉质量。根据欧洲关于肌肉疏松症定义和诊断的共识,对肌肉疏松症的风险进行了估计:结果:患有糖尿病的病例年龄更大(55 岁对 36 岁;P 结论:糖尿病与肌肉疏松症之间存在着错综复杂的关系:这项研究强调了糖尿病与肌肉疏松症之间错综复杂的关系,揭示了可改变的风险因素。研究发现,糖尿病患者患肌肉疏松症的可能性较高,这与体能水平较低和血甘油三酯较高有关。防止肌肉疏松症的保护因素包括女性、较高的体重指数和ALM/BMI比率。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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