Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI:10.1007/s10522-024-10136-4
Somayeh Ahmadi, Alka Hasani, Aytak Khabbaz, Vahdat Poortahmasbe, Samaneh Hosseini, Mohammad Yasdchi, Elham Mehdizadehfar, Zahra Mousavi, Roqaiyeh Hasani, Edris Nabizadeh, Javad Nezhadi
{"title":"Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity.","authors":"Somayeh Ahmadi, Alka Hasani, Aytak Khabbaz, Vahdat Poortahmasbe, Samaneh Hosseini, Mohammad Yasdchi, Elham Mehdizadehfar, Zahra Mousavi, Roqaiyeh Hasani, Edris Nabizadeh, Javad Nezhadi","doi":"10.1007/s10522-024-10136-4","DOIUrl":null,"url":null,"abstract":"<p><p>The gut-brain axis plays an important role in mental health. The intestinal epithelial surface is colonized by billions of commensal and transitory bacteria, known as the Gut Microbiota (GM). However, potential pathogens continuously stimulate intestinal immunity when they find the place. The last two decades have witnessed several studies revealing intestinal bacteria as a key factor in the health-disease balance of the gut, as well as disease-emergent in other parts of the body. Various neurological processes, such as cognition, learning, and memory, could be affected by dysbiosis in GM. Additionally, the aging process and longevity are related to systemic inflammation caused by dysbiosis. Commensal GM affects brain development, behavior, and healthy aging suggesting that building changes in GM might be a potential therapeutic method. The innovation in GM dysbiosis is intervention by Fecal Microbiota Transplantation (FMT), which has been confirmed as a therapy for recurrent Clostridium difficile infections and is promising for other clinical disorders, such as Parkinson's disease, Multiple Sclerosis (MS), Alzheimer's disease, and depression. Additionally, FMT may be possible to promote healthy aging, and extend longevity. This review aims to connect dysbiosis, neurological disorders, and aging and the potential of FMT as a therapeutic strategy to treat these disorders, and to enhance the quality of life in the elderly.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"957-983"},"PeriodicalIF":4.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biogerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10522-024-10136-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The gut-brain axis plays an important role in mental health. The intestinal epithelial surface is colonized by billions of commensal and transitory bacteria, known as the Gut Microbiota (GM). However, potential pathogens continuously stimulate intestinal immunity when they find the place. The last two decades have witnessed several studies revealing intestinal bacteria as a key factor in the health-disease balance of the gut, as well as disease-emergent in other parts of the body. Various neurological processes, such as cognition, learning, and memory, could be affected by dysbiosis in GM. Additionally, the aging process and longevity are related to systemic inflammation caused by dysbiosis. Commensal GM affects brain development, behavior, and healthy aging suggesting that building changes in GM might be a potential therapeutic method. The innovation in GM dysbiosis is intervention by Fecal Microbiota Transplantation (FMT), which has been confirmed as a therapy for recurrent Clostridium difficile infections and is promising for other clinical disorders, such as Parkinson's disease, Multiple Sclerosis (MS), Alzheimer's disease, and depression. Additionally, FMT may be possible to promote healthy aging, and extend longevity. This review aims to connect dysbiosis, neurological disorders, and aging and the potential of FMT as a therapeutic strategy to treat these disorders, and to enhance the quality of life in the elderly.

菌群失调与粪便微生物群移植:思考健康、神经变性和长寿方面的进展。
肠道-大脑轴在心理健康中发挥着重要作用。肠道上皮表面定植着数十亿个共生细菌和过渡性细菌,即所谓的肠道微生物群(GM)。然而,潜在的病原体一旦找到肠道,就会不断刺激肠道免疫。过去二十年来,多项研究表明,肠道细菌是肠道健康与疾病平衡的关键因素,也是身体其他部位疾病的诱发因素。转基因中的各种神经过程,如认知、学习和记忆,都可能受到菌群失调的影响。此外,衰老过程和长寿也与菌群失调引起的全身炎症有关。共生转基因影响大脑发育、行为和健康衰老,这表明改变转基因可能是一种潜在的治疗方法。粪便微生物群移植(FMT)是对转基因菌群失调进行干预的创新方法,已被证实可用于治疗复发性艰难梭菌感染,并有望用于治疗其他临床疾病,如帕金森病、多发性硬化症(MS)、阿尔茨海默病和抑郁症。此外,FMT 还有可能促进健康老龄化,延长寿命。本综述旨在将菌群失调、神经系统疾病和衰老联系起来,并探讨 FMT 作为一种治疗策略治疗这些疾病和提高老年人生活质量的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信