Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biopolymers Pub Date : 2024-09-27 DOI:10.1002/bip.23632

Nikita Udaipuria, Sankha Bhattacharya

{"title":"Novel Carbohydrate Polymer-Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials.","authors":"Nikita Udaipuria, Sankha Bhattacharya","doi":"10.1002/bip.23632","DOIUrl":null,"url":null,"abstract":"<p><p>Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.</p>","PeriodicalId":8866,"journal":{"name":"Biopolymers","volume":" ","pages":"e23632"},"PeriodicalIF":3.2000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/bip.23632","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH-responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon-specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli-responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.

查看原文本刊更多论文

基于碳水化合物聚合物的新型结肠癌精准给药系统：利用智能生物降解材料提高治疗效果。

碳水化合物聚合物具有生物相容性、生物可降解性和可控释放性，因此对于靶向给药系统，尤其是结肠癌治疗至关重要。本文探讨了壳聚糖、果胶、瓜尔豆胶、海藻酸、透明质酸、葡聚糖和硫酸软骨素等碳水化合物聚合物如何用于改进给药。对这些聚合物进行改性可改善药物的负载、稳定性和释放模式，从而提高化疗药物的治疗指数。壳聚糖纳米粒子具有 pH 值响应性，因此非常适合用于癌症治疗。果胶对胃酶和结肠细菌的耐受性使其成为一种很有前景的结肠特异性给药剂。将这些聚合物与纳米技术、3D 打印和人工智能相结合，可以创造出刺激响应系统，根据 pH 值、氧化还原电位或结肠酶活性等环境信号精确释放药物。这篇综述重点介绍了智能给药系统的设计进展，这些进展可降低全身毒性、提高治疗效果并改善患者的依从性。碳水化合物聚合物将彻底改变结肠癌的治疗方法，提供个性化和精确的替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.