Artificial blood for therapeutic and laboratory usage: Where do we stand?

IF 2.6 4区 工程技术 Q2 BIOCHEMICAL RESEARCH METHODS
Biomicrofluidics Pub Date : 2024-09-25 eCollection Date: 2024-09-01 DOI:10.1063/5.0186931
Pulak Kumar Ray, Pawan Kumar, Somnath Roy, Arup Kumar Das, Prasanta Kumar Das
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引用次数: 0

Abstract

The scarcity of blood for transfusion purposes has been widely acknowledged. Surgical therapeutic processes, war zones, and post-disaster treatments demand a huge amount of blood. Modern-day laboratories also require blood for bioengineering experimentation. Therefore, an artificially devised solution capable of mimicking the blood functions from biological and engineering relevance would be a noteworthy discovery of contemporary science. The experience drawn from discarded century-old blood substitutes has led us to technologically more advanced present-day solutions, which are better at carrying out the physiological functions of blood. Aiming at safety, stability, non-toxicity, and compatibility in terms of immuno-response, a remarkable number of substitutes are being tried to mimic the physiological properties and functions of red blood cells, platelets, plasma, and white blood cells. Despite significant efforts and time devoted, for transfusion, no product so far has been able to replace natural blood. This article puts together the important developments in blood substitutes that have evolved over the years, including substitutes for clinical as well as engineering requirements. It also points out the recent endeavors of synthesizing blood cells through modern synthetic routes. It has been highlighted that none of the blood substitutes have achieved the required efficacy so that they can be used in vivo. Finally, the emerging trends and future research needs have been stressed upon.

用于治疗和实验室的人造血液:现状如何?
用于输血的血液稀缺已得到广泛承认。外科治疗过程、战区和灾后治疗都需要大量血液。现代实验室的生物工程实验也需要血液。因此,能够从生物学和工程学角度模拟血液功能的人工设计方案将是当代科学的一项重大发现。从废弃的百年血液替代品中汲取的经验,让我们找到了技术上更先进的当今解决方案,它们能更好地实现血液的生理功能。为了保证安全性、稳定性、无毒性以及在免疫反应方面的兼容性,人们正在尝试大量的替代品来模拟红细胞、血小板、血浆和白细胞的生理特性和功能。尽管在输血方面投入了大量的精力和时间,但迄今为止还没有一种产品能够替代天然血液。本文总结了多年来血液替代品的重要发展,包括满足临床和工程需求的替代品。文章还指出了最近通过现代合成途径合成血细胞的努力。报告强调,目前还没有一种血液替代品达到所需的功效,因此无法在体内使用。最后,还强调了新出现的趋势和未来的研究需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomicrofluidics
Biomicrofluidics 生物-纳米科技
CiteScore
5.80
自引率
3.10%
发文量
68
审稿时长
1.3 months
期刊介绍: Biomicrofluidics (BMF) is an online-only journal published by AIP Publishing to rapidly disseminate research in fundamental physicochemical mechanisms associated with microfluidic and nanofluidic phenomena. BMF also publishes research in unique microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications. BMF offers quick publication, multimedia capability, and worldwide circulation among academic, national, and industrial laboratories. With a primary focus on high-quality original research articles, BMF also organizes special sections that help explain and define specific challenges unique to the interdisciplinary field of biomicrofluidics. Microfluidic and nanofluidic actuation (electrokinetics, acoustofluidics, optofluidics, capillary) Liquid Biopsy (microRNA profiling, circulating tumor cell isolation, exosome isolation, circulating tumor DNA quantification) Cell sorting, manipulation, and transfection (di/electrophoresis, magnetic beads, optical traps, electroporation) Molecular Separation and Concentration (isotachophoresis, concentration polarization, di/electrophoresis, magnetic beads, nanoparticles) Cell culture and analysis(single cell assays, stimuli response, stem cell transfection) Genomic and proteomic analysis (rapid gene sequencing, DNA/protein/carbohydrate arrays) Biosensors (immuno-assay, nucleic acid fluorescent assay, colorimetric assay, enzyme amplification, plasmonic and Raman nano-reporter, molecular beacon, FRET, aptamer, nanopore, optical fibers) Biophysical transport and characterization (DNA, single protein, ion channel and membrane dynamics, cell motility and communication mechanisms, electrophysiology, patch clamping). Etc...
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