Green Synthesis and Anti-Inflammatory Activity of Silver Nanoparticles Based on Leaves Extract of Aphania senegalensis.

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS
Biochemistry Research International Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI:10.1155/2024/3468868
Fatemata Diallo, Insa Seck, Samba Fama Ndoye, Tamsir Niang, Sidy Mouhamed Dieng, Fatou Thiam, Moussa Ndao, El Hadji Mamour Sakho, Alioune Fall, Madièye Séne, Matar Seck
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Abstract

This study focuses on the synthesis of silver nanoparticles (AgNPs) using the extract of Aphania senegalensis leaves. The extraction was done using maceration at room temperature in water for 48 h. The synthesized nanoparticles were characterized by IR, XRD, TEM, and SEM. The thermal stability of these nanoparticles was studied by TGA. The zeta potential was used to define the size, charge distribution, and stability of the nanoparticles. Optimization reactions were carried out based on reaction time, pH, and temperature. The nanoparticles obtained from optimal conditions were evaluated on induced inflammation. The determination of the average diameters and geometry of nanoparticles was carried out by XRD by calculating the lattice constants, and they are between 18.11 and 50 nm. The evaluation of anti-inflammatory activity showed that the nanoparticles are 10 times more active than the extract of Aphania senegalensis leaves. Minimum doses of 10 mg/kg orally and 3 mg/kg were obtained for the plant extract, respectively. These results are promising for the possibility of AgNPs to be used for the treatment of inflammation.

基于 Aphania senegalensis 叶提取物的银纳米粒子的绿色合成和抗炎活性。
本研究的重点是利用 Aphania senegalensis 叶子的提取物合成银纳米粒子 (AgNPs)。合成的纳米粒子通过红外光谱、XRD、TEM 和 SEM 进行了表征。热重分析法研究了这些纳米颗粒的热稳定性。zeta 电位用于确定纳米颗粒的尺寸、电荷分布和稳定性。根据反应时间、pH 值和温度进行了优化反应。对在最佳条件下获得的纳米颗粒进行了诱导炎症评估。通过 XRD 计算晶格常数,确定了纳米粒子的平均直径和几何形状,它们介于 18.11 纳米和 50 纳米之间。抗炎活性评估结果表明,纳米颗粒的活性比 Aphania senegalensis 叶子提取物高 10 倍。植物提取物的最小口服剂量分别为 10 毫克/千克和 3 毫克/千克。这些结果为 AgNPs 用于治疗炎症带来了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemistry Research International
Biochemistry Research International BIOCHEMICAL RESEARCH METHODS-
CiteScore
6.30
自引率
0.00%
发文量
27
审稿时长
14 weeks
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