Metabolites derived from radical oxidation of PUFA: NEO-PUFAs, promising molecules for health?

IF 4.9 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Atherosclerosis Pub Date : 2024-11-01 DOI:10.1016/j.atherosclerosis.2024.118600

Anna Abramova , Jamie Bride , Camille Oger , Marie Demion , Jean-Marie Galano , Thierry Durand , Jérôme Roy

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Abstract

Oxidative stress plays a critical role in numerous pathological processes. Under these stress conditions, the free radical-catalyzed lipid peroxidation generates in vivo a large number of key products that are involved in many physiological and pathophysiological processes. Among these products are neuroprostanes, which arise from the peroxidation of docosahexaenoic acid (DHA), and isoprostanes, resulting from arachidonic acid (AA) and eicosapentaenoic acid (EPA) through the same peroxidation process. These non-enzymatic oxygenated metabolites newly appointed NEO-PUFAs have gained recognition as reliable markers of oxidative stress in neurogenerative and cardiovascular diseases. Moreover, some of them display a wide range of biological activities. The ability to detect and measure these metabolites offers precious insights into the mechanisms of oxidative damage and holds potential therapeutic implications for various health conditions, including neurodegenerative diseases. This review focuses on the role of neuroprostanes as biomarkers for oxidative stress and related diseases, highlighting their potential applications in medical research and treatment.

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由 PUFA 自由基氧化产生的代谢物：NEO-PUFAs，有望促进健康的分子？

氧化应激在许多病理过程中起着至关重要的作用。在这些应激条件下，自由基催化的脂质过氧化反应会在体内产生大量参与许多生理和病理生理过程的关键产物。这些产物包括由二十二碳六烯酸（DHA）过氧化反应产生的神经前列素，以及由花生四烯酸（AA）和二十碳五烯酸（EPA）通过相同的过氧化反应过程产生的异前列素。这些新命名为 NEO-PUFAs 的非酶含氧代谢物已被公认为神经退行性疾病和心血管疾病中氧化应激的可靠标志物。此外，其中一些还具有广泛的生物活性。检测和测量这些代谢物的能力为了解氧化损伤的机制提供了宝贵的视角，并对包括神经退行性疾病在内的各种健康状况具有潜在的治疗意义。这篇综述重点探讨了神经前列素作为氧化应激和相关疾病生物标记物的作用，强调了它们在医学研究和治疗中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atherosclerosis 医学-外周血管病

CiteScore

9.80

自引率

3.80%

发文量

1269

审稿时长

36 days

期刊介绍： Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.