The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-09-26 DOI:10.1080/13813455.2024.2406895

Onur Ertik, Beril Kadıoğlu-Yaman, Ali Şen, Göksel Şener, Refiye Yanardag

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Abstract

Introduction: Postmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes.

Methods: For this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure.

Results: Evaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups.

Conclusion: It can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.

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桃金娘亚种对卵巢切除糖尿病大鼠肾脏和肠道组织的保护作用：体内和硅学方法。

导言：绝经后糖尿病影响着数百万妇女的生活质量。此外，糖尿病还会损害肾脏和小肠组织。本研究旨在探讨从香桃木叶中提取的提取物对肾脏和小肠组织的保护作用，以防止实验性绝经后糖尿病的发生：方法：将实验大鼠随机分为6组（对照组；卵巢切除组：OVX；糖尿病组：D；卵巢切除+糖尿病组：OVX+D；卵巢切除+糖尿病+雌激素组：OVX+D+E2；卵巢切除+糖尿病+MC组：OVX+D+MC），实验后取肾脏和小肠组织：结果：生化指标（谷胱甘肽和谷胱甘肽相关酶、抗氧化酶等）评价显示，MC对糖尿病组和卵巢切除组的肾脏和小肠组织有保护作用：结论：可以认为 MC 提取物对绝经后糖尿病患者的小肠和肾脏组织具有保护作用，可能是一种很好的草药来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.