Ovarian reserve does not influence natural conception: insights from infertile women

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Giulia Galati, Marco Reschini, Alessandra Chine’, Laura Benaglia, Paola Vigano’, Edgardo Somigliana, Paolo Vercellini, Ludovico Muzii
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Abstract

Purpose

There is several albeit not univocal evidence suggesting that ovarian reserve is not related to the chance of natural pregnancy, provided that the remnant follicular pool is sufficient to ensure regular menstrual cycles. Nevertheless, available studies have some methodological limitations, and the issue cannot be considered definitively ascertained.

Methods

To further address this issue, we retrospectively selected infertile women whose infertility diagnostic work-up was unremarkable (unexplained infertility-cases) and matched them by age and study period to a group of infertile women who were diagnosed with severe male infertility (controls). If ovarian reserve impacts on natural fertility, one had to expect lower ovarian reserve among women with unexplained infertility. Tested biomarkers included AMH, AFC and day 2–3 serum FSH. The primary aim was the frequency of women with serum AMH < 0.7 ng/ml.

Results

Two-hundred fifty-two women with unexplained infertility and 252 women with male infertility were included. All biomarkers of ovarian reserve did not differ between the study groups. AMH levels < 0.7 ng/mL were observed in 26 (10%) women with unexplained infertility and 35 (14%) women with male infertility (p = 0.28). The adjusted OR was 0.76 (95% CI: 0.44–1.33). Significant differences did not also emerge when repeating this dichotomous analysis using other biomarkers and other thresholds for the definition of low-ovarian reserve.

Conclusion

This study confirms that ovarian reserve is unremarkable to natural conception. Physicians and patients should be aware of this concept to avoid inappropriate counseling and undue clinical decisions.

卵巢储备并不影响自然受孕:不孕妇女的启示。
目的:有一些证据表明,卵巢储备与自然怀孕的几率无关,但前提是剩余卵泡库足以确保月经周期规律。然而,现有的研究在方法上存在一定的局限性,因此这一问题还不能被认为是明确的:为了进一步解决这一问题,我们回顾性地选择了不孕症诊断结果无异常的不孕妇女(不明原因不孕症病例),并按年龄和研究时期将她们与一组被诊断为严重男性不育症的不孕妇女(对照组)进行配对。如果卵巢储备对自然生育力有影响,那么我们就必须预期不明原因不孕妇女的卵巢储备较低。测试的生物标志物包括AMH、AFC和第2-3天血清FSH。主要目的是检测血清 AMH 的女性频率:共纳入 252 名不明原因不孕症妇女和 252 名男性不育症妇女。研究组之间卵巢储备的所有生物标志物均无差异。AMH水平 结论:这项研究证实,卵巢储备功能对自然受孕没有显著影响。医生和患者应了解这一概念,以避免不恰当的咨询和不当的临床决定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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