Assessing osteoporosis and bone mineral density through 18F-NaF uptake at lumbar spine.

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Jinquan Huang, Jingze Li, Zuguo Li, Jie Qin, Xingyu Mu, Wei Fu
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引用次数: 0

Abstract

Objectives: The use of 18F-Sodium fluoride (NaF) PET/CT is established in the detection of metastatic bone disease, yet its utility in osteoporosis remains underexplored. This research aims to assess the variations in 18F-NaF uptake among individuals with differing bone mineral density (BMD) and to examine the relationship between 18F-NaF uptake and BMD.

Methods: In this retrospective study, 199 patients (average age 56 ± 6, comprising 52 males and 147 females) with a history of cancer were analyzed. Each participant underwent both 18F-NaF PET/CT and lumbar dual-energy X-ray absorptiometry (DXA) scans within a span of 7 days. Based on DXA outcomes, patients and their lumbar vertebrae were categorized into normal BMD, osteopenia, and osteoporosis groups. The lumbar 18F-NaF uptake across these groups were compared, and to explore the association between lumbar standardized uptake values (SUV) values and BMD. The efficacy of 18F-NaF uptake in diagnosing osteoporosis or osteopenia was also evaluated. Analysis was conducted using Mann-Whitney U tests, Spearman regression, and receiver operating characteristic (ROC) curve analysis through GraphPad Prism 10.0.

Results: A total of 796 lumbar vertebrae from 199 patients were measured. It was observed that osteoporotic patients had significantly lower 18F-NaF uptake than those with osteopenia and normal BMD across the L1-L4 lumbar vertebrae (P < 0.0001). In a vertebra-based analysis, normal BMD vertebrae exhibited the highest maximum SUV(SUVmax) compared to osteopenic (8.13 ± 1.28 vs. 6.61 ± 1.01, P < 0.0001) and osteoporotic vertebrae (8.13 ± 1.28 vs. 4.82 ± 1.01, P < 0.0001). There was a positive correlation between lumbar 18F-NaF uptake and BMD across all vertebrae, with correlation coefficients exceeding 0.5 (range: 0.57-0.8). The area under the ROC curve values were notably high, at 0.96 for osteoporosis and 0.83 for osteopenia diagnosis.

Conclusion: This study demonstrates distinct 18F-NaF uptake patterns among individuals with varying BMD levels, with a positive correlation between 18F-NaF uptake and BMD. These findings highlight the potential of 18F-NaF PET/CT as a supportive diagnostic method in the management of osteoporosis.

通过腰椎的 18F-NaF 摄取评估骨质疏松症和骨矿物质密度。
目的:18F-氟化钠(NaF)PET/CT已被用于检测转移性骨病,但其在骨质疏松症中的应用仍未得到充分探索。本研究旨在评估不同骨矿密度(BMD)个体的 18F-NaF 摄取量差异,并探讨 18F-NaF 摄取量与 BMD 之间的关系:在这项回顾性研究中,分析了 199 名有癌症病史的患者(平均年龄 56 ± 6 岁,其中男性 52 人,女性 147 人)。每位受试者都在 7 天内接受了 18F-NaF PET/CT 和腰椎双能 X 光吸收测量(DXA)扫描。根据 DXA 的结果,患者及其腰椎被分为 BMD 正常组、骨质疏松组和骨质疏松症组。比较这些组别的腰椎18F-NaF摄取量,并探讨腰椎标准化摄取值(SUV)与BMD之间的关联。此外,还评估了 18F-NaF 摄取在诊断骨质疏松症或骨质疏松症方面的功效。分析采用 Mann-Whitney U 检验、Spearman 回归和 GraphPad Prism 10.0 的接收器操作特征曲线(ROC)分析:共测量了 199 名患者的 796 块腰椎骨。结果发现,与骨质疏松患者(8.13 ± 1.28 vs. 6.61 ± 1.01,P)相比,骨质疏松患者在 L1-L4 腰椎骨上的 18F-NaF 摄取量明显低于骨质疏松患者和 BMD 正常者(P 最大值),相关系数超过 0.5(范围:0.57-0.8)。ROC 曲线下面积值明显较高,骨质疏松症诊断为 0.96,骨质疏松症诊断为 0.83:这项研究表明,不同骨密度水平的人有不同的 18F-NaF 摄取模式,18F-NaF 摄取与骨密度呈正相关。这些发现凸显了 18F-NaF PET/CT 作为骨质疏松症管理辅助诊断方法的潜力。
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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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