Robert C Cole, Fred J DeGraves, John Schumacher, Jessica Brown
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引用次数: 0
Abstract
Objective: To determine the effect of 1.5 mL 2% mepivacaine, 0.75 mL 2% mepivacaine, and a combination of 0.75 mL 2% mepivacaine with epinephrine (1:200,000 solution) administered over each palmar digital nerve (PDN) to 6 horses with naturally occurring lameness caused by digital pain.
Methods: In a crossover study design, 6 horses with forefoot-related lameness were randomly assigned to 1 of 3 groups. Each group received, on different study days, a PDN block using 1.5 mL of 2% mepivacaine, 0.75 mL 2% mepivacaine, or 0.75 mL of a combination of 2% mepivacaine and epinephrine (1:200,000 solution) injected over each nerve. The horses' gait while trotting was analyzed with an inertial, sensor-based motion-analysis system immediately before treatment. The assigned treatment was then administered to the lame forelimb, after which the gait was reevaluated at 5-minute intervals for 15 minutes.
Results: All 3 treatments significantly reduced lameness scores at all gait evaluations, but the effect of treatment on the lameness score did not differ significantly among treatments.
Conclusions: 0.75 mL of mepivacaine hydrochloric acid injected over each PDN was as effective as twice that volume in decreasing the lameness score of horses with digital pain. The 0.75-mL solution of mepivacaine/epinephrine injected over each nerve did not significantly improve the anesthetic effect of mepivacaine.
Clinical relevance: For a palmar digital nerve block, a lower-than-commonly-recommended volume of 2% mepivacaine effectively ameliorates digital pain. This finding invites investigation as to whether administering a low volume of local anesthetic will more precisely localize pain.
目的确定在6匹因数字疼痛而自然跛行的马的掌部数字神经（PDN）上分别注射1.5 mL 2%甲哌卡因、0.75 mL 2%甲哌卡因以及0.75 mL 2%甲哌卡因与肾上腺素（1:200,000溶液）组合的效果：采用交叉研究设计，将6匹患有前足相关跛行的马随机分配到3个小组中的1个。每组在不同的研究日分别接受 1.5 mL 2% 甲哌卡因、0.75 mL 2% 甲哌卡因或 0.75 mL 2% 甲哌卡因和肾上腺素（1:200,000 溶液）组合的 PDN 阻滞注射。治疗前，先用惯性传感器运动分析系统分析马匹小跑时的步态。然后对跛行的前肢进行指定的治疗，之后每隔 5 分钟重新评估步态，持续 15 分钟：结果：在所有步态评估中，三种治疗方法都能明显降低跛行评分，但不同治疗方法对跛行评分的影响没有明显差异：结论：在每个PDN上注射0.75毫升盐酸甲哌卡因与两倍剂量的甲哌卡因一样，都能有效降低数字疼痛马的跛行评分。在每根神经上注射 0.75 毫升的甲哌卡因/肾上腺素溶液并不能显著提高甲哌卡因的麻醉效果：对于掌部数字神经阻滞，2%甲哌卡因的用量低于通常推荐的用量，可有效缓解数字疼痛。这一发现值得研究，即使用低剂量的局麻药是否能更精确地定位疼痛。
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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