Three-Year Outcomes After Posterior Nasal Neurectomy in Perennial Moderate and Severe Allergic Rhinitis Patients.

IF 2.5 3区医学 Q1 OTORHINOLARYNGOLOGY

American Journal of Rhinology & Allergy Pub Date : 2024-09-28 DOI:10.1177/19458924241281521

Bin Zhang, Jiayan Wang, Wei Wang, Ting Xu, Xujing Jia, Manman Chen, Ming Xu

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引用次数: 0

Abstract

Background: Posterior nasal neurectomy (PNN) has been shown to reduce the symptom burden of patients with perennial moderate and severe allergic rhinitis (AR).

Objectives: To evaluate the long-term safety and effectiveness of PNN for the treatment of perennial moderate and severe AR.

Methods: A prospective 3-year single-arm study was conducted in which the reflective total nasal symptom score (rTNSS) and total non-nasal symptom score (rTNNSS) were collected preoperatively and at 3 months, 6 months, 1 year, 2 years, and 3 years postoperatively.

Results: A total of 213 patients with AR were recruited and received PNN, of whom 154 patients completed the 3-year follow-up. The mean rTNSS of the long-term follow-up patients improved from 7.74 (95% confidence interval [CI] 7.507-7.974) at baseline to 2.604 (95% CI 2.221-2.986), P < .001, at 6 months and showed sustained improvement to 3.156 (95% CI 2.806-3.506), P < .001, at 3 years. The mean rTNNSS ranged from 1.301 (95% CI 1.112-1.491) at baseline to 0.564 (95% CI 0.441-0.688) (P < .001) at 6 months and showed sustained improvement to 0.641 (95% CI 0.533-0.749) (P < .001) at 3 years. The rTNSS subscores (sneezing, congestion, rhinorrhea, and itching) and rTNNSS subscores (lacrimation, eye itching, postnasal drip, and cough) remained significantly improved from the baseline at all follow-up time points (all P < .001).

Conclusion: Posterior nasal neurectomy significantly and sustainably alleviated nasal and non-nasal symptoms of perennial moderate and severe AR and improved patient quality of life through 3 years postprocedure.

查看原文本刊更多论文

常年中度和重度过敏性鼻炎患者鼻后神经切除术后的三年疗效。

背景：鼻后神经切除术（PNN事实证明，鼻后神经切除术（PNN）可减轻常年中度和重度过敏性鼻炎（AR）患者的症状负担：评估后鼻神经切断术治疗常年性中度和重度过敏性鼻炎的长期安全性和有效性：方法：进行一项为期 3 年的前瞻性单臂研究，收集术前以及术后 3 个月、6 个月、1 年、2 年和 3 年的反映性鼻症状总评分（rTNSS）和非鼻症状总评分（rTNNSS）：共招募了 213 名 AR 患者并对其进行了 PNN 治疗，其中 154 名患者完成了为期 3 年的随访。长期随访患者的 rTNSS 平均值从基线时的 7.74（95% 置信区间 [CI] 7.507-7.974）下降到 2.604（95% 置信区间 2.221-2.986），P P P P P 结论：鼻后部神经切除术可显著、持续地缓解常年中度和重度 AR 的鼻部和非鼻部症状，并在术后 3 年内改善患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Rhinology & Allergy 医学-耳鼻喉科学

CiteScore

5.60

自引率

11.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.