Choroid Involvement Secondary to Optic Disc Pit Maculopathy: OCT Analysis and Evolution After Surgical Treatment

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2024-09-27 DOI:10.1016/j.ajo.2024.09.022

Matteo Mario Carlà , Francesco Boselli , Federico Giannuzzi , Emanuele Crincoli , Tomaso Caporossi , Carlos Mateo , Stanislao Rizzo

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引用次数: 0

Abstract

Purpose

To assess choroidal changes associated to optic disc pit maculopathy (ODP-M) and their evolution after surgical treatment.

Design

Multicentric retrospective case series.

Methods

An analysis of 42 patients affected by unilateral ODP-M undergoing surgical treatment between 2013 and 2023 was conducted. Optical coherence tomography (OCT) was performed at baseline and postoperative months 1, 6, 12, and 24 and most recent follow-up. Subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) were measured in ODP-M and fellow eyes. The presence of retinal pigmented epithelium (RPE) atrophy was used to distinguish between “early” and “advanced” disease, and data regarding fluid localization were collected.

Results

Baseline SFCT in ODP-M eyes was significantly higher than fellow eyes (386.8 ± 88.9 vs 334.4 ± 72.2 µm, P = 0.002), in contrast to PPCT (192.6 ± 47.8 vs 181.2 ± 45.7 µm, P = .46). SFCT significantly decreased 1 month postoperatively (mean reduction 36.5 µm, P = .009) and remained below preoperative values throughout the follow-up, showed a mean reduction of 79.4 µm at final follow-up (P < .001). Conversely, PPCT showed no changes between preoperative and postoperative values (all P > .05). Nine eyes (21.4%) showed submacular dilated choroidal vessels, correlated with the presence of subretinal fluid (P = .008) and reducing in caliber after surgical treatment. The 10 eyes (23.8%) with advanced disease had lower baseline SFCT and worse best-corrected visual acuity compared to the early disease subgroup, and showed a delayed reduction of choroidal swelling postoperatively.

Conclusions

Subfoveal choroid may thicken and remodel in response to ODP-M, eventually returning to physiological values after surgical treatment. Moreover, the presence of RPE atrophy may influence retino-choroidal balance. Conversely, PPCT did not show comparable modifications.

查看原文本刊更多论文

继发于视盘凹陷性黄斑病变的脉络膜受累：OCT分析和手术治疗后的演变：视盘凹陷黄斑病变中的脉络膜受累。

目的：评估与视盘凹陷性黄斑病变（ODP-M）相关的脉络膜变化及其手术治疗后的演变情况：多中心回顾性病例系列：分析2013年至2023年期间接受手术治疗的42例单侧ODP-M患者。在基线和术后第1、6、12、24个月及最近一次随访时进行光学相干断层扫描（OCT）。测量了ODP-M和同侧眼的眼底脉络膜厚度（SFCT）和毛周脉络膜厚度（PPCT）。视网膜色素上皮（RPE）萎缩的存在被用来区分 "早期 "和 "晚期 "疾病，并收集有关液体定位的数据：ODP-M眼的基线SFCT明显高于其他眼（386.8±88.9 vs. 334.4±72.2μm，p=0.002），不同于PPCT（192.6±47.8 vs. 181.2±45.7μm，p=0.46）。SFCT 在术后 1 个月明显减少（平均减少 36.5 μm，p=0.009），并在整个随访期间保持在术前值以下，最终随访时平均减少 79.4 μm（p0.05）。九只眼（21.4%）的脉络膜下血管扩张，与视网膜下积液的存在相关（p=0.008），手术治疗后口径缩小。与 "早期 "亚组相比，10 只 "晚期 "病变眼（23.8%）的基线 SFCT 较低，BCVA 较差，术后脉络膜肿胀的消退也较迟：结论：眼底脉络膜可能会因 ODP-M 而增厚和重塑，最终在手术治疗后恢复到生理值。此外，RPE萎缩可能会影响视网膜-脉络膜的平衡。相反，PPCT 并未显示出类似的改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.