Yu-Xin Hu, Can Hu, Min Hu, Yi-Peng Gao, Wen-Sheng Dong, Kang Li, Yun-Jia Ye, Xin Zhang
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引用次数: 0
Abstract
Fibronectin (FN) can bind to certain integrin receptors on the cell surface through short peptide sequences, thereby transmitting extracellular stimuli to intracellular effector molecules. FNDC4 plays a similar role due to the constitution of a type III FN domain, which is a binding site for DNA, heparin, or cell surface. It mainly functions as a signal transmitter after being cleaved and secreted as the extracellular N-terminal fibronectin type III domain (sFNDC4). Emerging studies have shown that FNDC4 plays crucial roles in numerous diseases and holds significant implications for guiding clinical treatment. This review aims to summarize the different roles and the latest advances of FNDC4 in the development of various diseases, in order to provide new ideas for clinical treatment.
纤连蛋白（FN）可通过短肽序列与细胞表面的某些整合素受体结合，从而将细胞外的刺激传递给细胞内的效应分子。FNDC4 由于具有 III 型 FN 结构域，是 DNA、肝素或细胞表面的结合位点，因此发挥着类似的作用。它在作为细胞外 N 端纤维连接蛋白 III 型结构域（sFNDC4）被裂解和分泌后，主要起信号传递作用。最新研究表明，FNDC4 在多种疾病中发挥着关键作用，对指导临床治疗具有重要意义。本综述旨在总结 FNDC4 在各种疾病发生发展中的不同作用和最新进展，从而为临床治疗提供新思路。
期刊介绍：
Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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