Exploring the potential of nanomedicine for gene therapy across the physicochemical and cellular barriers

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2024-09-28 DOI:10.1007/s10142-024-01459-z

Huma Hameed, Hafiz Shoaib Sarwar, Komel Younas, Muhammad Zaman, Muhammad Jamshaid, Ali Irfan, Maha Khalid, Muhammad Farhan Sohail

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引用次数: 0

Abstract

After COVID-19, a turning point in the way of pharmaceutical technology is gene therapy with beneficial potential to start a new medical era. However, commercialization of such pharmaceuticals would never be possible without the help of nanotechnology. Nanomedicine can fulfill the growing needs linked to safety, efficiency, and site-specific targeted delivery of Gene therapy-based pharmaceuticals. This review's goal is to investigate how nanomedicine may be used to transfer nucleic acids by getting beyond cellular and physicochemical barriers. Firstly, we provide a full description of types of gene therapy, their mechanism, translation, transcription, expression, type, and details of diseases with possible mechanisms that can only be treated with genes-based pharmaceuticals. Additionally, we also reviewed different types of physicochemical barriers, physiological and cellular barriers in nucleic acids (DNA/RNA) based drug delivery. Finally, we highlight the need and importance of cationic lipid-based nanomedicine/nanocarriers in gene-linked drug delivery and how nanotechnology can help to overcome the above-discussed barrier in gene therapy and their biomedical applications.

Graphical abstract

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跨越物理化学和细胞障碍，探索纳米药物用于基因治疗的潜力。

继 COVID-19 之后，基因疗法成为制药技术的一个转折点，有望开启一个新的医学时代。然而，如果没有纳米技术的帮助，此类药物的商业化将永远无法实现。纳米医学可以满足以基因治疗为基础的药物在安全、高效和特定部位靶向给药方面日益增长的需求。本综述旨在探讨如何利用纳米医学超越细胞和物理化学障碍来传输核酸。首先，我们全面介绍了基因治疗的类型、机制、翻译、转录、表达、类型，以及只能用基于基因的药物治疗的具有可能机制的疾病详情。此外，我们还综述了基于核酸（DNA/RNA）的药物递送过程中不同类型的物理化学障碍、生理障碍和细胞障碍。最后，我们强调了以阳离子脂质为基础的纳米药物/纳米载体在基因链接药物递送中的必要性和重要性，以及纳米技术如何帮助克服基因治疗及其生物医学应用中的上述障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?