Integrated identification and detection of hydration state and its evolution using terahertz technology.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-01 Epub Date: 2024-09-24 DOI:10.1016/j.talanta.2024.126943

Rong Zhao, Qiang Niu, Ghulam Murtaza, Guling Zhang, Yuping Yang

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引用次数: 0

Abstract

The accurate detection of dehydration processes in hydrated drugs can reveal various intermolecular vibration modes mediated by hydrogen bonds between water molecules and other components, which underpin the further development of pharmaceutical science, food safety and biophysics. Herein, terahertz (THz) technology is utilized to investigate the dehydration state of d(+)-Raffinose pentahydrate (Rf·5H₂O), in conjunction with imaging-based point by point scanning data acquisition and barcodes methods, to establish an innovative platform integrated identification, trace detection, and application capabilities. Our study demonstrates that the dehydration process of Rf·5H₂O can be dynamically monitored through the evolution of its THz absorption peaks, offering more precise results compared to XRD and Raman spectroscopies. Moreover, the absorbance spectra data collected at each individual pixel is utilized to build visualized THz images, achieving an ultralow minimum content required for detection of 0.032 μg/(50 μm)². Additionally, we introduce a THz spectra-barcode conversion system that not only ensures efficient electronic recordkeeping but also enhances user readability, thereby facilitating the practical applications of THz technology.

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利用太赫兹技术综合识别和检测水合状态及其演变。

准确检测水合药物的脱水过程可以揭示由水分子和其他成分之间的氢键介导的各种分子间振动模式，从而为制药科学、食品安全和生物物理学的进一步发展奠定基础。本文利用太赫兹（THz）技术研究了五水 d(+)-Raffinose (Rf-5H2O)的脱水状态，并结合基于成像的逐点扫描数据采集和条形码方法，建立了一个集识别、痕量检测和应用功能于一体的创新平台。我们的研究表明，Rf-5H2O 的脱水过程可通过太赫兹吸收峰的演变进行动态监测，与 XRD 和拉曼光谱相比，能提供更精确的结果。此外，我们还利用在每个像素上收集到的吸收光谱数据来构建可视化太赫兹图像，从而实现了 0.032 μg/（50 μm）2 的超低检测最低含量要求。此外，我们还介绍了一种太赫兹光谱-条形码转换系统，它不仅能确保高效的电子记录保存，还能提高用户的可读性，从而促进太赫兹技术的实际应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.