Determination of 4-n-butylresorcinol by fluorescence derivatization based on dopamine.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-01 Epub Date: 2024-09-20 DOI:10.1016/j.talanta.2024.126909

Qing Liu, Si Chen, Yiming Nie, Qian Li, Fang Chen

引用次数: 0

Abstract

4-n-butylresorcinol (4nBR) is a frequently utilized as whitening ingredients in skincare cosmetics. Compared with other whitening ingredients, it can effectively inhibit tyrosinase with lower toxicity and superior inhibition efficacy. Under alkaline conditions, an induced oxidative coupling reaction can occur between 4nBR and dopamine (DA) to generate strong fluorescent substance azamonardine with an intense emission band centering at 476 nm when excited at 440 nm. This phenomenon can be used to establish a fluorescence analysis method for 4nBR. The results indicated that the linear range of the method was 1.0-24.0 nmol L^-1, and the detection limit was as low as 0.25 nmol L^-1. The method showed high sensitivity, good selectivity, mild experimental conditions and low cost. The proposed method was successfully used to detect 4nBR in cosmetics, and the results were consistent with those of HPLC. The spiking recoveries were between 98.2% and 108 %.

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基于多巴胺的荧光衍生法测定 4-正丁基间苯二酚。

4-正丁基间苯二酚（4nBR）是护肤化妆品中常用的美白成分。与其他美白成分相比，它能有效抑制酪氨酸酶，毒性较低，抑制效果显著。在碱性条件下，4nBR 与多巴胺（DA）之间会发生诱导氧化偶联反应，生成强荧光物质氮杂萘啶，在 440 纳米波长下激发时，以 476 纳米波长为中心形成一条强发射带。这一现象可用于建立 4nBR 的荧光分析方法。结果表明，该方法的线性范围为1.0-24.0 nmol L-1，检出限低至0.25 nmol L-1。该方法灵敏度高、选择性好、实验条件温和、成本低。该方法成功用于化妆品中4nBR的检测，结果与高效液相色谱法一致。加标回收率为98.2%～108%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.