Fructose intake, endogenous biomarkers and latent metabolic construct in adolescents: Exploring path associations and mediating effects.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-09-28 DOI:10.1111/ijpo.13176

Pei-Wen Wu, Yu-Ting Chin, Wei-Ting Lin, Sharon Tsai, Chun-Ying Lee, Wei-Chung Tsai, David W Seal, Chien-Hung Lee

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引用次数: 0

Abstract

Background: Uric acid (UA) and homeostatic model assessment of insulin resistance (HOMA-IR) are endogenous biomarkers implicated in metabolic disorders and dysfunction.

Objectives: To investigate the structural associations between sugar-sweetened beverage intake (SSB), UA, HOMA-IR and adolescent latent MetS construct (MetsC) representing paediatric metabolic syndrome (MetS).

Methods: A population-based representative adolescent cohort (n = 1454) was evaluated for risk profiles of MetS. Structural equation modelling was performed to identify multifactor structural associations between study parameters and evaluate mediating effects.

Results: Adolescents had a single-factor latent construct representing MetS. Increased SSB intake was associated with higher UA and HOMA-IR levels, and the two biomarkers were positively associated with the MetsC score. UA and HOMA-IR exerted three mediating effects on the association between fructose-rich tea beverage (FTB) intake of >500 mL/day and MetsC: adjusted standardized coefficient and mediating effect (%), FTB → UA → MetsC: 0.071, 23.1%; FTB → HOMA-IR → MetsC: 0.034, 11.0%; FTB → UA → HOMA-IR → MetsC: 0.010, 3.1%. The UA-associated pathways accounted for 31.1% of the overall mediation on the association between bottled sugar-containing beverage intake and MetsC. After accounting for the UA- and HOMA-IR-derived detrimental effects, the fructose-rich tea beverage intake of >500 mL/day had a tea-related beneficial effect on MetsC, with an adjusted standardized coefficient of -0.103.

Conclusions: UA and HOMA-IR individually and jointly mediate the adverse effects of high fructose-rich SSB intake on the mechanisms underlying paediatric MetS. Fructose-free tea-based beverages may have a beneficial effect on latent MetS structure in adolescents.

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青少年的果糖摄入量、内源性生物标志物和潜在代谢结构：探索路径关联和中介效应。

背景：尿酸（UA）和胰岛素抵抗稳态模型评估（HOMA-IR）是与代谢紊乱和功能障碍有关的内源性生物标志物：研究含糖饮料摄入量（SSB）、UA、HOMA-IR 和代表儿科代谢综合征（MetS）的青少年潜在 MetS 结构（MetsC）之间的结构关联：方法：对一个具有人口代表性的青少年队列（n = 1454）进行了 MetS 风险概况评估。进行了结构方程建模，以确定研究参数之间的多因素结构关联，并评估中介效应：结果：青少年有一个代表 MetS 的单因素潜在结构。固体饮料摄入量的增加与较高的 UA 和 HOMA-IR 水平相关，这两种生物标志物与 MetsC 评分呈正相关。UA和HOMA-IR对富含果糖的茶饮料（FTB）摄入量大于500毫升/天与MetsC之间的关联有三种中介效应：调整后的标准化系数和中介效应（%），FTB→UA→MetsC：0.071，23.1%；FTB→HOMA-IR→MetsC：0.034，11.0%；FTB→UA→HOMA-IR→MetsC：0.010，3.1%。在瓶装含糖饮料摄入量与 MetsC 之间关系的总体中介作用中，UA 相关途径占 31.1%。在考虑了UA和HOMA-IR的不利影响后，富含果糖的茶饮料摄入量大于500毫升/天对MetsC有茶相关的有益影响，调整后的标准化系数为-0.103：UA和HOMA-IR可单独或共同调节富含果糖的高浓度固体饮料摄入对小儿MetS潜在机制的不利影响。不含果糖的茶饮料可能会对青少年潜在的 MetS 结构产生有益影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.