Main oral characteristics and treatment of ligneous gingivitis and periodontitis in individuals with plasminogen deficiency: A systematic review.

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Special Care in Dentistry Pub Date : 2024-09-27 DOI:10.1111/scd.13068

Diego Belmiro do Nascimento Santos, Larissa Conrado da Silva, Isabelle do Vale Dantas da Silva, Bruno Augusto Benevenuto de Andrade, Lucianne Cople Maia, Jefferson R Tenório

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引用次数: 0

Abstract

Objective: This systematic review evaluated the main clinical, radiographic, histopathological and treatment-related characteristics of ligneous gingivitis (LG) and periodontitis (LP) in individuals with plasminogen deficiency (PD).

Material and methods: Studies in humans diagnosed with PD, focusing on the evaluation of oral characteristics and treatment of the LG/LP were considered for inclusion criteria. Electronic searches were performed up to April 2024 in five databases and in the grey literature. Risk of bias was assessed according to the Joanna Briggs Institute Critical Appraisal Checklists for case reports. It was provided a narrative synthesis of the results.

Results: A total of 17 studies were included. All were case reports that analyzed 17 individuals with PD who presented with LG/LP. The relative frequency of PD type I was 56%, while type II constitutes the remaining 44%. In most studies, patients exhibited ulceration clinically, bone loss radiographically, and subepithelial eosinophilic material accumulation on histopathological evaluation. Conventional periodontal scaling was the most used management. All included studies provided well-described clinical characteristics and confirmed plasminogen deficiency through laboratory testing. Only three studies had a risk of bias values lower than 15%.

Conclusions: Current evidence is limited and varied, complicating the diagnosis and treatment of GL/PL. Future studies should provide a more detailed account of treatments and include extended clinical and radiographic follow-up.

查看原文本刊更多论文

纤溶酶原缺乏症患者龈炎和牙周炎的主要口腔特征和治疗方法：系统综述。

目的：本系统综述评估了纤溶酶原缺乏症（PD）患者龈炎（LG）和牙周炎（LP）的主要临床、影像学、组织病理学和治疗相关特征：材料和方法：纳入标准考虑了对诊断为 PD 患者的研究，这些研究侧重于评估 LG/LP 的口腔特征和治疗方法。截至 2024 年 4 月，在五个数据库和灰色文献中进行了电子检索。根据乔安娜-布里格斯研究所（Joanna Briggs Institute）病例报告批判性评估清单对偏倚风险进行了评估。对结果进行了叙述性综述：共纳入 17 项研究。所有研究均为病例报告，分析了17名出现LG/LP的帕金森病患者。PDⅠ型的相对发生率为56%，而Ⅱ型占其余的44%。在大多数研究中，患者在临床上表现为溃疡，在影像学上表现为骨质流失，在组织病理学评估中表现为上皮下嗜酸性物质堆积。传统的牙周刮治是最常用的治疗方法。所有纳入的研究都提供了详尽的临床特征描述，并通过实验室检测证实了纤溶酶原缺乏症。只有三项研究的偏倚风险值低于15%：目前的证据有限且多种多样，使得GL/PL的诊断和治疗变得更加复杂。未来的研究应更详细地介绍治疗方法，并进行更长时间的临床和放射学随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Special Care in Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.40

自引率

14.30%

发文量

120

期刊介绍： Special Care in Dentistry is the official journal of the Special Care Dentistry Association, the American Association of Hospital Dentists, the Academy of Dentistry for Persons with Disabilities, and the American Society for Geriatric Dentistry. It is the only journal published in North America devoted to improving oral health in people with special needs.